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- W3029073791 abstract "ObjectiveTo compare the effects and safety of entecavir(ETV) and tenofovir disoproxil fumarate(TDF) in initial treatment of patients with chronic hepatitis B virus infection.Methods52 chronic HBV infection cases were randomly divided into initially treated with tenofovir(TDF group) or entecavir(ETV group) in this retrospective study.The following parameters were assessed: HBeAg status, serum alanine aminotransferase(ALT), and HBV-DNA levels at weeks 4, 8, 12, 24, 36, 48, 72, and 96; total duration of follow-up and adverse reactions.ResultsThe clinical characteristics of two groups had no statistically significant difference.At 8 weeks, the response rate was significantly higher in the TDF group than in ETV group(23.1% vs.50.0%, χ2=4.266, P=0.045). Less patients administered ETV showed undetectable HBV-DNA levels compared with the TDF group in late treatment(weeks 12-96), the differences were not statistically significant (all P>0.05), as well as HBeAg seroconversion rate(all P>0.05). No adverse reactions were found.ConclusionETV and TDF are comparable in efficacy and safety to suppress HBV-DNA replication in CHB patients.Key words: Hepatitis, type B, chronic; Entecavir; Tenofovir disoproxil fumarate" @default.
- W3029073791 created "2020-06-05" @default.
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- W3029073791 date "2016-12-15" @default.
- W3029073791 modified "2023-09-24" @default.
- W3029073791 title "Comparison of efficacy of tenofovir and entecavir in initial treatment of chronic hepatitis B virus infection" @default.
- W3029073791 doi "https://doi.org/10.3760/cma.j.issn.1008-6706.2016.24.027" @default.
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