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- W3029085087 abstract "支气管哮喘(简称哮喘)是一种常见的呼吸道疾病,以气道高反应性和气道炎症为主要特征.近年有诸多研究表明其机制与活性氧的过度产生有关[1,2],氧自由基所致的生化紊乱和组织结构破坏可能是哮喘的发病基础.对于有哮喘病史的患者,麻醉手术中有多种因素可诱发哮喘发作和支气管痉挛,如气管内插管不当、麻醉深度不够、药物选择不当、分泌物对气道的刺激等,严重威胁着病人生命安全.丙泊酚对气道平滑肌具有一定的舒张作用,常用于哮喘病人的麻醉诱导和维持.由于其与内源性抗氧化剂生育酚(VitE)的结构上的相似性,使其在理论上具有一定的抗氧化作用.为进一步探讨丙泊酚在哮喘防治中的作用,本实验观察了丙泊酚对哮喘大鼠血浆丙二醛(MDA)及其诱导释放的炎症介质血栓素(TXB2)的影响,为指导临床用药提供理论依据。" @default.
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- W3029085087 date "2006-10-15" @default.
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- W3029085087 title "Effects of propofol on oxyradical and TXA in the asthmatic rats" @default.
- W3029085087 doi "https://doi.org/10.3760/cma.j.issn.1673-4378.2006.05.004" @default.
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