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- W3029093296 abstract "目的 探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与胰岛素抵抗(IR)的相关性及其可能的发病机制.方法 82例打鼾者根据多导睡眠图检查结果分为:OSAHS组42例,均为中、重度患者(AHI＞20);对照组40例,两组年龄、性别、血压相匹配.比较两组一般资料(年龄、性别、体质量指数、呼吸紊乱指数、最低血氧饱和度)、血清指标[空腹血糖、空腹胰岛素、胰岛素敏感指数、甘油三脂、胆固醇、脂蛋白a(LPa)、尿酸],并作统计学分析.结果 一般资料比较:体质量指数、呼吸紊乱指数、最低血氧饱和度组间差异有统计学意义;血清指标比较:除LPa外,其余各项组间差异均有统计学意义.卡方检验显示两组糖尿病的发病率差异有统计学意义.相关分析显示OSAHS组呼吸紊乱指数与胰岛素敏感指数呈显著负相关(r＝-0.415,P＝0.006),与空腹胰岛素呈显著正相关(r＝0.402,P＝0.008).在控制多个变量的影响后,逐步回归分析显示呼吸紊乱指数与体重指数对胰岛素敏感指数具有显著性影响.结论 中、重度OSAHS患者胰岛素敏感性下降,存在IR,两者呈独立相关关系.OSAHS与肥胖、糖耐量低减、高血压、高甘油三脂共同为IR的重要致病因素。" @default.
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- W3029093296 date "2007-03-05" @default.
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- W3029093296 title "Clinical research on obstructive sleep apnea hypopnea syndrome and insulin resistance" @default.
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