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- W3029099556 abstract "ObjectiveTo investigate the significance of modified gold nanocages (GNCs) in photothermal therapy and radiosensitivity enhancement for murine mammary carcinoma 4T1 cells.MethodsA molecule probe, CD44-PEG-GNCs, was constructed on the basis of GNCs. Inductively coupled plasma mass spectrometry (ICP-MS) and transmission electron microscopy (TEM) were used to analyze Au uptake by 4T1 cells. The cell counting kit-8(CCK-8) assay was used to determine the impact of the probe on the viability of 4T1 cells. The CCK-8 assay and the Hoechst/PI double staining were used to evaluate the photothermal killing effects of near infrared laser (NIR). The colony forming assay and the Hoechst/PI double staining were used to measure the viability of 4T1 cells after irradiation with 6 MV of X-ray.ResultsICP-MS and TEM showed that 4T1 cells had an uptake of a large number of GNCs, in which the number of CD44-PEG-GNCs taken up by 4T1 was 3-4 times larger than that of PEG-GNCs. The cell toxicity assay revealed that in a certain range of concentration, GNCs showed little effect on the viability of 4T1 cells, which was reduced to 81.2% in 48 hours. The CCK-8 assay, the Hoechst/PI double staining, and the colony forming assay showed that after NIR irradiation and radiotherapy, large-scale apoptosis was induced in CD44-PEG-GNCs-contained tumor cells by photothermal therapy combined with radiotherapy, which had substantially better outcomes than other groups.ConclusionsThe GNC-based molecular probe actively targets 4T1 cells with little cytotoxicity, indicating that it enhances the sensitivity of tumor towards photothermal therapy and radiotherapy.Key words: Molecular probe; Photothermal therapy; Radiosensitivity; Breast neoplasms" @default.
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- W3029099556 date "2016-04-15" @default.
- W3029099556 modified "2023-09-24" @default.
- W3029099556 title "Significance of modified gold nanocages in photothermal therapy and radiosensitivity enhancement" @default.
- W3029099556 doi "https://doi.org/10.3760/cma.j.issn.1004-4221.2016.04.022" @default.
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