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- W3029100261 abstract "ObjectiveTo systematically evaluate the effectiveness and safety of topical administration of tranexamic acid for total knee arthroplasty(TKA) in order to provide evidence for clinical application of tranexamic acid.MethodsDatabases including PubMed, EMbase, CENTRAL(Issue 3, 2015), WanFang Data, CBM, CNKI were searched to collect the randomized controlled trails(RCT) about tranexamic acid for total knee arthroplasty from inception to March 2015. Two researchers independently screened the literatures, extracted the data and evaluated the quality of the methods according to the inclusion and exclusion criteria. The Meta-analysis was conducted using RevMan 5.3 software.ResultsA total of 16 RCT involving 1 533 patients were included. 10 RCT compared with placebo and 6 RCTs compared with intravenous usage. The results of Meta-analysis showed that: Compared with placebo, the incidence of transfusion rate had reduced[odds ratio(OR)=0.3, 95%CI(0.19-0.46)](P 0.05).ConclusionsThe topical administration of tranexamic acid is an effective and safe method of reducing the need for blood transfusion after total knee arthroplasty without increasing the incidence of deep venous thrombosis. Compared with intravenous tranexamic acid, Topical administration had no clear superiority. Due to the limited number of research, the above conclusion is still needed large volume, high quality trials to verified.Key words: Tranexamic acid; Total knee arthroplasty; Systematic review; Meta-analysis" @default.
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- W3029100261 date "2017-03-15" @default.
- W3029100261 modified "2023-09-26" @default.
- W3029100261 title "The safety and effectiveness of the topical administration of tranexamic acid in total knee arthroplasty: a systematic review" @default.
- W3029100261 doi "https://doi.org/10.3760/cma.j.issn.1673-4378.2017.03.008" @default.
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