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- W3029103672 abstract "Objective To explore the association between the genetic polymorphism of hypoxia inducible factor 1 α (HIF-1α) G1790A and the radiosensitivity of nasopharyngeal carcinoma.Methods A total of 189 patients with nasopharyngeal carcinoma treated with radical radiotherapy were followed-up for 3 years.The patients were divided into cured group with 135 cases and recurrence group with 54 cases by clinical follow-up results.PCR-RFLP was used to determine the mononucleotide genotypes of HIF-1α G1790A.Results The observed genotype frequencies of HIF-1α gene 1790 (G→A) for GG, GA and AA were 70.04% , 20.74% , 2.22% in cured group and 59.26% , 38.89% , 1.85% in recurrence group, respectively.The allele frequencies for G and A were 87.4% , 13.9% in cured groups and 78.7% ,21.3% in recurrence group, respectively, without significant difference in distribution of allele frequencies between the two groups(x2 =6.919, P =0.077).Conclusions The genetic polymorphisms of HIF-1α G1790A might be related with the radiosensitivity of nasopharyngeal carcinoma.Key words: H ypoxia inducible factor 1 α; Single nucleotidepolymorphism; Nasopharyngeal carcinoma; Radiosensitivity" @default.
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- W3029103672 date "2011-08-25" @default.
- W3029103672 modified "2023-09-28" @default.
- W3029103672 title "Genetic polymorphism of HIF-1α G1790A associated with radiosensitivity of nasopharyngeal carcinoma" @default.
- W3029103672 doi "https://doi.org/10.3760/cma.j.issn.0254-5098.2011.04.013" @default.
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