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- W3029104145 abstract "Objective To explore the effects of ambroxol on ventilator induced lung injury (VILI)by analying the changes of surfactant protein A (SP-A) and myeloperoxidase (MPO) in lung of rats with mechanical ventilation. Methods Twenty-four health Wistar rats were randomly divided into there groups: control group, mechanical ventilation group (MV group) and ambroxol pretreatment group (AMB group). The pathological changes of the lungs and the neutrophil counts in bronchoalveolar lavage fluid (BALF) were detected, the protein level in BALF was measured by brillant blue method. MPO activity in BALF and lung tissue was determined, the expressions of SP-A mRNA and protein in lung tissue were determined by reverse transcription-polymerase chain reaction and immunohistochemistry staining. Results Compared with control group and AMB group,the neutrophil counts and MPO activity obviously increased (all P ＜0.01), and the expressions of SP-A mRNA and protein in lung obviously decreased (all P ＜0.01) in MV group. There was no statistical significance between control group and AMB group on these indicators. Correlation analysis showed that the expression of SP-A was negatively correlated with the activity of MPO ( r = -0. 775, P ＜0. 05). Conclusions SP-A and MPO play an important role in the development of VILI. Ambroxol may have protective effects on VILI by decreasing the activity of MPO and increasing the expressions of SP-A mRNA and protein in lung of rats with mechanical ventilation.Key words: Mechanical ventilation; Lung injury; Surfactant protein A; Myeloperoxidase; Ambroxol" @default.
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- W3029104145 date "2011-03-20" @default.
- W3029104145 modified "2023-09-25" @default.
- W3029104145 title "Effects of ambroxol on expression of surfactant protein A and myeloperoxidase in lung of rats with mechanical ventilation" @default.
- W3029104145 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2011.006.008" @default.
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