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- W3029121722 abstract "ObjectiveTo explore the impact of Enalapril-folic acid tablet on development of contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in elderly patients with coronary heart diseases(CHD) complicated with mild renal insufficiency.MethodsA total of 935 old patients (≥60 years) undergoing selective PCI at our hospital from January 2013 to June 2016 were enrolled in this retrospective study.Based on treatments during the perioperative phase, the 935 patients were divided into Enalapril-folic acid tablet intervention group (n=296, 31.7%), and other RAS blocker control group with Angiotensin eonverting-enzyme inhibitor (ACEI) or Angiotensin Ⅱ receptor blocker (ARB) (n=639, 68.3%). The levels of serum creatinine for 72 hours after operation were monitored and evaluated.Baseline data and CIN incidence were compared between two groups.The clinical events within 1 month after contrast media application were recorded.Multivariate Logistic regression analysis was used to analyze independent risk factors for CIN after PCI.ResultsThe incidence of CIN after PCI was lower in the intervention group than in the control group with no statistical significance[7.1% (21/296) vs.11.1% (71/639), χ2=3.679, P=0.059]. Multivariate regression analysis showed that age (OR=1.103, P=0.001), hypertension (OR=3.362, P=0.017), and hyper-homocysteinemia (OR=3.528, P=0.003) were independent risk factors, but the treatment with Enalapril-folic acid tablet might be a protective factor for development of CIN after PCI (OR=0.443, P=0.042). During the 1-month follow-up, the rate of recurrent angina pectoris was lower in the intervention group than in the control group (P 0.05).ConclusionsThe treatment with enalapril-folic acid tablet may prevent the occurrence of CIN after PCI in elderly patients with coronary heart disease and mild renal insufficiency.Key words: Enalapril; Folic acid; Cysteine; Nephrosis; Contrast media" @default.
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- W3029121722 date "2018-09-14" @default.
- W3029121722 modified "2023-09-24" @default.
- W3029121722 title "Effect of Enalapril-folic acid tablet on development of contrast-induced nephropathy after percutaneous coronary intervention in elderly patients with coronary heart diseases complicated with mild renal insufficiency" @default.
- W3029121722 doi "https://doi.org/10.3760/cma.j.issn.0254-9026.2018.09.003" @default.
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