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- W3029121970 abstract "目的在1型糖尿病患者中，下消化道症状不常出现，而且血糖控制和生活质量对其影响尚不清楚。本研究的目的是确定血糖控制和生活质量对下消化道症状患病率的影响，并研究其潜在的病因。研究设计和方法次级治疗的前瞻性队列研究。1型糖尿病患者完成胃肠症状问卷，并填写36份V.2生活质量调查表，并进行血红蛋白A1c测定。腹泻患者按国家指南进行重新评估和调查。对照组为非糖尿病患者，比较消化道症状患病率和生活质量评分。结果有706例合并1型糖尿病患者（平均年龄41.9岁）和604例对照患者（平均年龄41.9岁）入组。与对照组相比，1型糖尿病患者的胃肠道症状频次显著增加，尤其是便秘[比值比（OR）2.4]、腹泻（OR 2.5）、排便习惯改变（OR 2.1）、腹痛（OR 1.4）、稀便（OR 2.7）、腹胀（OR 1.4）和胀气（OR 1.3）（均P<0.05）。曾经患胰腺炎在1型糖尿病患者中更为常见（OR 4.6），但其他胃肠道疾病则不常见。胃肠道症状与血糖控制较差（P<0.01）和生活质量差有关，尤其是腹泻患者。对腹泻，包括排便习惯改变患者（n=105）的研究表明，在随后的管理变化中确定了72.3%的病因。结论1型糖尿病患者胃肠道症状的患病率是非糖尿病人群的2倍，并与较差的生活质量和血糖控制有关。1型糖尿病患者腹泻，应给予治疗，且控制糖尿病可使四分之三症状得以缓解。" @default.
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- W3029121970 date "2018-09-18" @default.
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- W3029121970 title "Lower gastrointestinal symptoms are associated with worse glycemic control and quality of life in type 1 diabetes mellitus" @default.
- W3029121970 doi "https://doi.org/10.3760/cma.j.issn.1007-9742.2018.09.121" @default.
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