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- W3029122443 abstract "目的研究大鼠颅脑创伤后Na。1．1和Na，1．2的mRNA和蛋白在海马中的表达情况。 方法对成年SD大鼠实施脑液压伤后分别在伤后2，12，24和72 h处死，取伤侧海马行荧 光定量PCR和Western blot以及免疫荧光染色等方法检测Na，1．1和Na。1．2的mRNA和蛋白表达 情况。 结果大鼠脑液压伤后Na，1．1和Na。1．2的mRNA表达显著下调(P 0．05)。结论颅脑创伤导致了大鼠海马钠通道仅亚单位mRNA和蛋白表达的显著改变，这可能 是颅脑创伤后神经元细胞膜上的钠通道功能异常及其诱发的兴奋性毒性作用的分子学基础之一。" @default.
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- W3029122443 date "2009-04-15" @default.
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- W3029122443 title "Abnormal expressions of Nav1.1 and Nav1.2 in hippocampus following traumatic brain injury in rats" @default.
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