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- W3029123575 abstract "ObjectiveTo investigate the relationship of Toll-like receptors（TLRs）2 and 4 with the occurrence of chloasma.MethodsPeripheral blood samples were collected from 40 patients with chloasma and 40 healthy human controls, and skin samples were also collected from the lesions of 10 of the patients and normal skin of 10 of the healthy controls. Real time（RT）-PCR was performed to measure the mRNA expressions of TLR2 and TLR4 in skin lesions and blood samples. An immunohistochemical test was conducted to observe the expressions of TLR2 and TLR4 in skin lesions. Statistical analysis was carried out by t test.ResultsThe expressions of TLR2 and TLR4 mRNAs were both significantly higher in skin lesions of the patients than in normal skin of the controls（9.72 ± 2.93 vs. 5.10 ± 2.69, t = 3.67, P 0.05）. As the immunohistochemical test revealed, TLR2 was absent in both the epidermis and vascular endothelial cells in 6 normal control skin samples, weakly expressed in the basal layer of the epidermis but absent in vascular endothelial cells in 4 normal skin samples, and no TLR4 expression was observed in either the epidermis or vascular endothelial cells in these control skin samples. Among the 10 skin samples from chloasma lesions, 3 showed TLR2 expression in the whole epidermis, 7 in both basal cell layer and prickle cell layer but not in vascular endothelial cells in the superficial dermal layer, all showed strong TLR4 expression in the basal cell layer and weak TLR4 expression in the prickle cell layer, and 3 exhibited TLR4 expression in vascular endothelial cells in the superficial dermal layer.ConclusionTLR-mediated immune responses in local skin might be related to the occurrence of chloasma.Key words: Chloasma; Toll-like receptors; Inflammation" @default.
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- W3029123575 date "2015-02-15" @default.
- W3029123575 modified "2023-09-28" @default.
- W3029123575 title "Expressions of Toll-like receptors 2 and 4 in skin lesions and peripheral blood from patients with chloasma" @default.
- W3029123575 doi "https://doi.org/10.3760/cma.j.issn.0412-4030.2015.02.010" @default.
- W3029123575 hasPublicationYear "2015" @default.
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