Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029123634> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3029123634 endingPage "237" @default.
- W3029123634 startingPage "232" @default.
- W3029123634 abstract "ObjectiveThe aim of the study was to analyze the expression of YWHAZ in cutaneous melanoma, and to evaluate its association with survival of melanoma patients and biological function.MethodsThe GEO database was used to explore the difference in YWHAZ expression between cutaneous melanoma and benign melanocytic nevi. TCGA database was used to analyze the correlation between YWHAZ expression and melanoma prognosis. The biological function of YWHAZ was investigated in vitro through gene knockdown using siRNA against YWHAZ. Cell proliferation was detected by CCK8 assay, cell apoptosis was analyzed by flow cytometry, and cell migration and invasion abilities were evaluated by Transwell assay.ResultsAccording to the GEO dataset GSE3189, we found that YWHAZ was highly expressed in cutaneous melanoma tissues (5.785±0.128) compared to benign melanocytic nevi [(4.704±0.281), t=4.023, P=0.0002]. The TCGA cutaneous melanoma data showed that high YWHAZ expression was associated with a shorter overall survival. Loss-of-function studies demonstrated that YWHAZ knockdown could inhibit melanoma cell proliferation, migration, and invasion, and promote cell apoptosis.ConclusionYWHAZ is overexpressed in cutaneous melanoma and associates with a shorter overall survival. Increased expression of YWHAZ can promote the malignant biological behavior of melanoma cells.Key words: Melanoma; YWHAZ; Oncogenes; Prognosis" @default.
- W3029123634 created "2020-06-05" @default.
- W3029123634 creator A5018372804 @default.
- W3029123634 creator A5041554723 @default.
- W3029123634 creator A5048913550 @default.
- W3029123634 creator A5055356574 @default.
- W3029123634 creator A5068116429 @default.
- W3029123634 date "2020-03-15" @default.
- W3029123634 modified "2023-09-23" @default.
- W3029123634 title "Clinical and biological significance of YWHAZ in cutaneous melanoma" @default.
- W3029123634 doi "https://doi.org/10.3877/cma.j.issn.1674-0785.2020.03.016" @default.
- W3029123634 hasPublicationYear "2020" @default.
- W3029123634 type Work @default.
- W3029123634 sameAs 3029123634 @default.
- W3029123634 citedByCount "0" @default.
- W3029123634 crossrefType "journal-article" @default.
- W3029123634 hasAuthorship W3029123634A5018372804 @default.
- W3029123634 hasAuthorship W3029123634A5041554723 @default.
- W3029123634 hasAuthorship W3029123634A5048913550 @default.
- W3029123634 hasAuthorship W3029123634A5055356574 @default.
- W3029123634 hasAuthorship W3029123634A5068116429 @default.
- W3029123634 hasConcept C1491633281 @default.
- W3029123634 hasConcept C153911025 @default.
- W3029123634 hasConcept C173396325 @default.
- W3029123634 hasConcept C190283241 @default.
- W3029123634 hasConcept C2777658100 @default.
- W3029123634 hasConcept C502942594 @default.
- W3029123634 hasConcept C54355233 @default.
- W3029123634 hasConcept C553184892 @default.
- W3029123634 hasConcept C62112901 @default.
- W3029123634 hasConcept C86803240 @default.
- W3029123634 hasConceptScore W3029123634C1491633281 @default.
- W3029123634 hasConceptScore W3029123634C153911025 @default.
- W3029123634 hasConceptScore W3029123634C173396325 @default.
- W3029123634 hasConceptScore W3029123634C190283241 @default.
- W3029123634 hasConceptScore W3029123634C2777658100 @default.
- W3029123634 hasConceptScore W3029123634C502942594 @default.
- W3029123634 hasConceptScore W3029123634C54355233 @default.
- W3029123634 hasConceptScore W3029123634C553184892 @default.
- W3029123634 hasConceptScore W3029123634C62112901 @default.
- W3029123634 hasConceptScore W3029123634C86803240 @default.
- W3029123634 hasIssue "03" @default.
- W3029123634 hasLocation W30291236341 @default.
- W3029123634 hasOpenAccess W3029123634 @default.
- W3029123634 hasPrimaryLocation W30291236341 @default.
- W3029123634 hasRelatedWork W1528169997 @default.
- W3029123634 hasRelatedWork W1971387995 @default.
- W3029123634 hasRelatedWork W2023597079 @default.
- W3029123634 hasRelatedWork W2026986677 @default.
- W3029123634 hasRelatedWork W2073802219 @default.
- W3029123634 hasRelatedWork W2077700239 @default.
- W3029123634 hasRelatedWork W2414417189 @default.
- W3029123634 hasRelatedWork W2547692803 @default.
- W3029123634 hasRelatedWork W2576480513 @default.
- W3029123634 hasRelatedWork W2791569098 @default.
- W3029123634 hasRelatedWork W2889946849 @default.
- W3029123634 hasRelatedWork W2927440955 @default.
- W3029123634 hasRelatedWork W2954133473 @default.
- W3029123634 hasRelatedWork W2987784165 @default.
- W3029123634 hasRelatedWork W3024990160 @default.
- W3029123634 hasRelatedWork W3128795717 @default.
- W3029123634 hasRelatedWork W3177066877 @default.
- W3029123634 hasRelatedWork W3195548465 @default.
- W3029123634 hasRelatedWork W3205534143 @default.
- W3029123634 hasRelatedWork W3030101268 @default.
- W3029123634 hasVolume "14" @default.
- W3029123634 isParatext "false" @default.
- W3029123634 isRetracted "false" @default.
- W3029123634 magId "3029123634" @default.
- W3029123634 workType "article" @default.