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- W3029123850 abstract "目的研究丙烯酰胺(AA)对人角质形成细胞的细胞毒性和对DNA的损伤及其可能机制.方法(1)人角质形成细胞株HaCaT细胞经AA浓度梯度染毒44h后,以四氮唑盐(MTI)法检测细胞存活率.(2)细胞经AA浓度梯度染毒,以彗星试验检测细胞DNA损伤.(3)细胞经2.00 mmol/LAA和0.50 mmol/L的细胞色素P-450(CYP-450)抑制剂1-ABT共处理4 h后,以彗星试验探索DNA损伤与CYP-450的关系.结果(1)细胞毒性试验显示,AA染毒44h后细胞存活率显著下降.(2)AA染毒4 h未观察到细胞毒性,但各组细胞的DNA较对照组均检测到显著损伤,且损伤程度随染毒剂量增大而加重,彗尾长度在处理剂量范围内有明显的剂量效应关系;细胞经1-ABT和2.00 mmol/L AA共同处理后,拖尾率和尾长为15.4%和(8.2±2.0)μm,较2.00mmol/L AA组[80.6%和(44.3±4.0)μm]明显降低,差异有显著性(P＜0.01).结论AA对HaCaT细胞具有细胞毒性和基因毒性,AA诱导的DNA损伤可能与其经CYP-450作用产生的氧化代谢物有关." @default.
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- W3029123850 date "2003-03-20" @default.
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- W3029123850 title "Effects of acrylamide on DNA damage in human keratinocytes" @default.
- W3029123850 doi "https://doi.org/10.3760/cma.j.issn.1001-9391.2003.02.006" @default.
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