FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029123921> ?p ?o ?g. }

• W3029123921 abstract "Abstract Background Chronic kidney disease (CKD) has an apparent sex disparity, with a more rapid progress in men than in women. Whether the well-established sex-specific evolutionary biology trade-off between reproduction and longevity might inform CKD has not previously been considered. Relevant evidence from randomized controlled trials (RCTs) is not available. Methods We used a bi-directional Mendelian randomization study to obtain unconfounded estimates using the UK Biobank. Single nucleotide polymorphisms (SNPs) that strongly ( p value < 5 × 10 −8 ) predicted testosterone in a sex-specific manner were applied to 179,916 white British men (6016 CKD cases) and 212,079 white British women (5958 CKD cases) to obtain sex-specific associations with CKD, albuminuria, and estimated glomerular filtration rate (eGFR). We also used multivariable MR to control for sex hormone binding globulin (SHBG). For validation, we similarly examined their role in hemoglobin and high-density lipoprotein cholesterol (HDL-c). We also assessed the role of kidney function in serum testosterone, by applying eGFR-related SNPs to testosterone in the UK Biobank. Results Genetically predicted testosterone was associated with CKD in men (odds ratio (OR) for bioavailable testosterone 1.17 per standard deviation, 95% confidence interval (CI) 1.03 to 1.33) based on 125 SNPs but not in women (OR 1.02, 95% CI 0.92 to 1.14 for total testosterone) based on 254 SNPs. Multivariable MR allowing for SHBG showed consistent patterns. Genetically predicted bioavailable testosterone in men and women and genetically predicted total testosterone in women increased hemoglobin and lowered HDL-c, as seen in RCTs. Genetically predicted eGFR was not related to serum testosterone in men or in women. Conclusions Genetically predicted testosterone was associated with CKD and worse kidney function in men, whilst not affected by kidney function. Identifying drivers of testosterone and the underlying pathways could provide new insights into CKD prevention and treatment." @default.
• W3029123921 created "2020-06-05" @default.
• W3029123921 creator A5036765539 @default.
• W3029123921 creator A5073476241 @default.
• W3029123921 date "2020-06-04" @default.
• W3029123921 modified "2023-10-14" @default.
• W3029123921 title "The role of testosterone in chronic kidney disease and kidney function in men and women: a bi-directional Mendelian randomization study in the UK Biobank" @default.
• W3029123921 cites W1907953089 @default.
• W3029123921 cites W1965675690 @default.
• W3029123921 cites W1972696558 @default.
• W3029123921 cites W1977133287 @default.
• W3029123921 cites W1977631420 @default.
• W3029123921 cites W1983846424 @default.
• W3029123921 cites W1984060669 @default.
• W3029123921 cites W1996784253 @default.
• W3029123921 cites W2003677715 @default.
• W3029123921 cites W2010986951 @default.
• W3029123921 cites W2035645373 @default.
• W3029123921 cites W2035829354 @default.
• W3029123921 cites W2038393188 @default.
• W3029123921 cites W2082704080 @default.
• W3029123921 cites W2099294505 @default.
• W3029123921 cites W2099814945 @default.
• W3029123921 cites W2101969517 @default.
• W3029123921 cites W2108038333 @default.
• W3029123921 cites W2118625269 @default.
• W3029123921 cites W2149659795 @default.
• W3029123921 cites W2153662687 @default.
• W3029123921 cites W2154985550 @default.
• W3029123921 cites W2155533485 @default.
• W3029123921 cites W2155965977 @default.
• W3029123921 cites W2164249826 @default.
• W3029123921 cites W2164571725 @default.
• W3029123921 cites W2189732555 @default.
• W3029123921 cites W2279912337 @default.
• W3029123921 cites W2324862792 @default.
• W3029123921 cites W2412136682 @default.
• W3029123921 cites W2463336269 @default.
• W3029123921 cites W2490272499 @default.
• W3029123921 cites W2513596750 @default.
• W3029123921 cites W2516157700 @default.
• W3029123921 cites W2560843419 @default.
• W3029123921 cites W2567680867 @default.
• W3029123921 cites W2723723801 @default.
• W3029123921 cites W2738903518 @default.
• W3029123921 cites W2740662778 @default.
• W3029123921 cites W2742117056 @default.
• W3029123921 cites W2773482211 @default.
• W3029123921 cites W2785099367 @default.
• W3029123921 cites W2792062570 @default.
• W3029123921 cites W2800798499 @default.
• W3029123921 cites W2803072880 @default.
• W3029123921 cites W2818417770 @default.
• W3029123921 cites W2913651649 @default.
• W3029123921 cites W2932813327 @default.
• W3029123921 cites W2947278243 @default.
• W3029123921 cites W2950885009 @default.
• W3029123921 cites W2954615909 @default.
• W3029123921 cites W2967418188 @default.
• W3029123921 cites W2988724547 @default.
• W3029123921 cites W3004892753 @default.
• W3029123921 cites W4210703904 @default.
• W3029123921 cites W4252771015 @default.
• W3029123921 doi "https://doi.org/10.1186/s12916-020-01594-x" @default.
• W3029123921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7271464" @default.
• W3029123921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32493397" @default.
• W3029123921 hasPublicationYear "2020" @default.
• W3029123921 type Work @default.
• W3029123921 sameAs 3029123921 @default.
• W3029123921 citedByCount "35" @default.
• W3029123921 countsByYear W30291239212020 @default.
• W3029123921 countsByYear W30291239212021 @default.
• W3029123921 countsByYear W30291239212022 @default.
• W3029123921 countsByYear W30291239212023 @default.
• W3029123921 crossrefType "journal-article" @default.
• W3029123921 hasAuthorship W3029123921A5036765539 @default.
• W3029123921 hasAuthorship W3029123921A5073476241 @default.
• W3029123921 hasBestOaLocation W30291239211 @default.
• W3029123921 hasConcept C104317684 @default.
• W3029123921 hasConcept C126322002 @default.
• W3029123921 hasConcept C134018914 @default.
• W3029123921 hasConcept C135763542 @default.
• W3029123921 hasConcept C153209595 @default.
• W3029123921 hasConcept C156957248 @default.
• W3029123921 hasConcept C159641895 @default.
• W3029123921 hasConcept C2775871022 @default.
• W3029123921 hasConcept C2777911890 @default.
• W3029123921 hasConcept C2778653478 @default.
• W3029123921 hasConcept C2779279991 @default.
• W3029123921 hasConcept C2779901538 @default.
• W3029123921 hasConcept C2993967602 @default.
• W3029123921 hasConcept C30092816 @default.
• W3029123921 hasConcept C42407357 @default.
• W3029123921 hasConcept C54355233 @default.
• W3029123921 hasConcept C71315377 @default.
• W3029123921 hasConcept C71924100 @default.
• W3029123921 hasConcept C86803240 @default.
• W3029123921 hasConceptScore W3029123921C104317684 @default.
• W3029123921 hasConceptScore W3029123921C126322002 @default.
• W3029123921 hasConceptScore W3029123921C134018914 @default.

• next