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- W3029125600 abstract "目的 探讨右美托咪啶预先给药对罗哌卡因诱发大鼠心肌毒性阈值的影响.方法 健康Wistar大鼠28只,雌雄不拘,8～12周龄,体重250～350 g,采用随机数字表法,将其随机分为4组(n=7):罗哌卡因组(R组)、低剂量右美托咪啶+罗哌卡因组(D1组)、中剂量右美托咪啶+罗哌卡因组(D2组)和高剂量右美托咪啶+罗哌卡因组(D3组).D1组、D2组和D3组分别经10 min静脉输注右美托咪啶5、10、15 μg/kg,R组给予等容量生理盐水0.5 ml,停止给予右美托咪啶后4组均静脉输注1％罗哌卡因1 ml/h至发生心肌毒性.记录发生心肌毒性时罗哌卡因剂量和时间,发生心肌毒性时采集动脉血样,测定血浆罗哌卡因浓度.结果 与R组比较,D1组、D2组和D3组罗哌卡因剂量增加,发生心肌毒性时间延长,血浆罗哌卡因浓度升高(P＜0.05)；D1组、D2组和D3组间上述指标差异均无统计学意义(P＞0.05).结论 右美托咪啶预先给药可升高罗哌卡因诱发大鼠心肌毒性的阈值,但是与右美托咪啶剂量无关。" @default.
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- W3029125600 date "2011-12-20" @default.
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- W3029125600 title "Effects of dexmedetomidine pretreatment on the threshold for cardiotoxicity induced by ropivacaine in rats" @default.
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