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• W3029126461 abstract "ObjectiveTo explore the specific mechanism of pancreatic kallikrein(PKK) renal disease in type 2 diabetic mice.MethodsA total number of 20(4 week- old) db/db mice were randomly divided into 2 groups depending on their body weights and blood glucose. One group was treated with PKK (PKK group,n=10, 60 U·kg-1·d-1, intraperitoneal injection), while the other was given saline (DM group,n= 10, 1 ml/g, intraperitoneal injection). In addition, littermates db/m mice (NC group,n=8, 1 ml/g, intraperitoneal injection) were given saline as non- diabetic control group. Blood glucose and body weight were measured weekly, and both systolic and diastolic blood pressure were monitored monthly. After treated for 16 weeks, mice were sacrificed and kidney tissues were collected. Light microscopy and transmission electron microscope were used to examine the tubular pathological changes and the ultrastructure, respectively. Immunohistochemistry were performed to detect the expression of epithelial- cadherin (E- cadherin). Real- time PCR was applied to determine the gene expression of interleukin- 1β (IL- 1β) and fibronectin in the whole kidney.Results(1) After 16 weeks,both blood glucose and body weight in DM and PKK group were significantly higher than NC group, and the kidney weight /body mass index was lower than NC group (blood glucose for NC,DM and PKK group were (5.4±0.6), (27.4±4.6), (26.9±3.0) mmol/L, expectively (F=86.35,P<0.01) ; Body weights were (24.3±3.1), (42.6±4.8), (41.5±2.6) g, expectively (F= 38.82,P<0.01) ; the kidney weight/body mass index were 12.52±2.53, 9.01±1.25, 9.83±1.18, expectively (F=7.27,P<0.01) ). However, there wasn' t any difference between DM and PKK group. Both systolic and diastolic blood pressures showed no differences between any two groups. (2)The results of transmission electron microscope showed that PKK treatment could significantly improve cellular mitochondrial swelling which was present in both the proximal and distal tubular epithelial cells in DM group. Meanwhile, PKK could also increase the number of mitochondria and ameliorate lipid metabolism disorders in proximal tubular cells as compared to DM group. (3) Compared with NC group, E- cadherin expression was significantly decreased in DM group, while the PKK treatment significantly increased the expression of E- cadherin. Quantitative PCR showed that PKK could significantly decrease the gene expression of IL-1β and fibronectin as compared with DM group.ConclusionsPKK has protective effects on tubules of db/db mice, which was independent of improvements in blood pressure and blood glucose. The renoprotective effect of PKK might be mediated by reducing inflammation, anti- fibrosis and decreasing the epithelial to mesenchymal transition.Key words: Pancreatic kallikrein; Diabetic nephropathy; db/db Mice" @default.
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• W3029126461 date "2014-12-27" @default.
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• W3029126461 title "Pancreatic kallikrein protects renal tubule in db/db diabetic mice" @default.
• W3029126461 doi "https://doi.org/10.3760/cma.j.issn.1674-5809.2014.12.009" @default.
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