Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029127042> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W3029127042 endingPage "270" @default.
- W3029127042 startingPage "268" @default.
- W3029127042 abstract "Objective To study the effect of CTLA4Ig and rapamycin therapy on islet xenotransplantation. Methods Streptozotocin-induced diabetic C57BL/6 mice were transplanted (Tx) under the kidney capsule with rat islets and randomly divided into following groups: group 1, control group, i.e. islet Tx without any therapy; group 2, rapamycin group (0. 2 mg/kg by oral garage at day 0, 1, 2 and every other day to 14); group 3, anti-CD154 mAb (MRI) group (0. 5 mg i. p on day 0, 2 and 4); group 4, CTLA4Ig group (0. 5 nag i. p on day 0, 2, 4 and 6); group 5 (combination therapy with CTLA4Ig and rapamycin); group 6 (combination therapy with CTLA4Ig and MR1);group 7 (combination therapy with CTLA4Ig, MR1 and rapamycin). Mice were followed for islet function by glycemia and histology was performed at time of rejection and 200 days after Tx. Results Rapamycin, MR1, CTLA4Ig therapy alone significantly prolonged rat xenograft survival compared to control group [median graft survival (MGS) 34 days, 98 days and 77 days vs. 17 days, respectively,P＜0. 05), but rejection still occurred. Combination therapy of CTLA4Ig + rapamycin allowed significantly prolonged graft survival compared with control group (MGS 130 days) (P＜0. 01 ). Combination therapy of CTLA4Ig + MR1 and CTLA4Ig + MR1 + rapamycin allowed indefinite graft survival (MGS ＞200 days and ＞200 days respectively). Histological analysis showed severe xenografts destruction at rejection. At day of 200 post-Tx, CTLA4Ig + rapamycin treated mouse grafts showed positive staining for insulin and glucagon, and no cellular infiltration within the grafts. Conclusion Long-term survival of concordant islet xenografts was achieved by combination therapy of CTLA4Ig and rapamycin.Key words: Graft survival; Islets of Langerhans transplantation; Mice; Animals,outbred strains; Sirolimus" @default.
- W3029127042 created "2020-06-05" @default.
- W3029127042 creator A5020994793 @default.
- W3029127042 creator A5061418054 @default.
- W3029127042 creator A5091019805 @default.
- W3029127042 date "2008-05-20" @default.
- W3029127042 modified "2023-09-23" @default.
- W3029127042 title "Short term CTLA4Ig and rapamycin therapy significantly prolongs survival of islet xenografts" @default.
- W3029127042 doi "https://doi.org/10.3760/cma.j.issn.0254-1785.2008.05.003" @default.
- W3029127042 hasPublicationYear "2008" @default.
- W3029127042 type Work @default.
- W3029127042 sameAs 3029127042 @default.
- W3029127042 citedByCount "0" @default.
- W3029127042 crossrefType "journal-article" @default.
- W3029127042 hasAuthorship W3029127042A5020994793 @default.
- W3029127042 hasAuthorship W3029127042A5061418054 @default.
- W3029127042 hasAuthorship W3029127042A5091019805 @default.
- W3029127042 hasConcept C126322002 @default.
- W3029127042 hasConcept C126894567 @default.
- W3029127042 hasConcept C134018914 @default.
- W3029127042 hasConcept C165220095 @default.
- W3029127042 hasConcept C16685009 @default.
- W3029127042 hasConcept C2776914184 @default.
- W3029127042 hasConcept C2776999253 @default.
- W3029127042 hasConcept C2777300124 @default.
- W3029127042 hasConcept C2777921159 @default.
- W3029127042 hasConcept C2778442404 @default.
- W3029127042 hasConcept C2779280383 @default.
- W3029127042 hasConcept C2780252810 @default.
- W3029127042 hasConcept C2911091166 @default.
- W3029127042 hasConcept C555293320 @default.
- W3029127042 hasConcept C71924100 @default.
- W3029127042 hasConceptScore W3029127042C126322002 @default.
- W3029127042 hasConceptScore W3029127042C126894567 @default.
- W3029127042 hasConceptScore W3029127042C134018914 @default.
- W3029127042 hasConceptScore W3029127042C165220095 @default.
- W3029127042 hasConceptScore W3029127042C16685009 @default.
- W3029127042 hasConceptScore W3029127042C2776914184 @default.
- W3029127042 hasConceptScore W3029127042C2776999253 @default.
- W3029127042 hasConceptScore W3029127042C2777300124 @default.
- W3029127042 hasConceptScore W3029127042C2777921159 @default.
- W3029127042 hasConceptScore W3029127042C2778442404 @default.
- W3029127042 hasConceptScore W3029127042C2779280383 @default.
- W3029127042 hasConceptScore W3029127042C2780252810 @default.
- W3029127042 hasConceptScore W3029127042C2911091166 @default.
- W3029127042 hasConceptScore W3029127042C555293320 @default.
- W3029127042 hasConceptScore W3029127042C71924100 @default.
- W3029127042 hasIssue "05" @default.
- W3029127042 hasLocation W30291270421 @default.
- W3029127042 hasOpenAccess W3029127042 @default.
- W3029127042 hasPrimaryLocation W30291270421 @default.
- W3029127042 hasRelatedWork W2047427464 @default.
- W3029127042 hasRelatedWork W2094395651 @default.
- W3029127042 hasRelatedWork W2351559122 @default.
- W3029127042 hasRelatedWork W2353043746 @default.
- W3029127042 hasRelatedWork W2356319391 @default.
- W3029127042 hasRelatedWork W2362217828 @default.
- W3029127042 hasRelatedWork W2369018387 @default.
- W3029127042 hasRelatedWork W2373897802 @default.
- W3029127042 hasRelatedWork W2374920660 @default.
- W3029127042 hasRelatedWork W2379833947 @default.
- W3029127042 hasRelatedWork W2387035360 @default.
- W3029127042 hasRelatedWork W2393230969 @default.
- W3029127042 hasRelatedWork W2400217640 @default.
- W3029127042 hasRelatedWork W2410025294 @default.
- W3029127042 hasRelatedWork W2748788671 @default.
- W3029127042 hasRelatedWork W2921785495 @default.
- W3029127042 hasRelatedWork W3029042856 @default.
- W3029127042 hasRelatedWork W3030932036 @default.
- W3029127042 hasRelatedWork W3032434624 @default.
- W3029127042 hasRelatedWork W3148981202 @default.
- W3029127042 hasVolume "29" @default.
- W3029127042 isParatext "false" @default.
- W3029127042 isRetracted "false" @default.
- W3029127042 magId "3029127042" @default.
- W3029127042 workType "article" @default.