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- W3029127048 abstract "ObjectiveTo study and analyze the related factors of lung injury caused by three-dimensional conformal radiotherapy and clinical outcomes of treatment for patients with advanced non-small-cell lung cancer (NSCLC). MethodsA total of 118 patients with advanced NSCLC who were treated in the Second People’s Hospital of Datong from May 2012 to May 2015 were selected. All patients were diagnosed by pathology, of which the clinical data and treatment protocols were collected. The correlation between three-dimensional conformal radiotherapy and lung injury was analyzed. Patients were randomly divided into control groups and observation group, with 59 cases in each group. Patients in control group underwent radiotherapy alone and patients in observation group were treated by three-dimensional conformal radiotherapy. The clinical efficacy and incidence of adverse reactions were compared between the two groups. ResultsThe effective rate of observation group (88.14%) was significantly higher than that of control group (69.49%), P<0.05; the incidence of adverse reactions in observation group (13.56%) was significantly lower than that in control group (32.20%), P<0.05. The factor analysis results showed that the average lung dose, percentage of lung volume (V20) and tumor volume were related influencing factors of lung injury. Logistic linear regression analysis confirmed that the average lung dose was an independent risk factor of the occurrence of lung injury (P<0.05). ConclusionsThe clinical effect of three-dimensional conformal on patients with advanced NSCLC is significant, but there are few adverse reactions. And lung injury caused by advanced NSCLC is closely related to the average lung dose, V20 and tumor volume.Key words: Three-dimensional conformal radiotherapy; Non-small cell lung cancer; Lung injury; Lung function" @default.
- W3029127048 created "2020-06-05" @default.
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- W3029127048 date "2018-10-10" @default.
- W3029127048 modified "2023-09-28" @default.
- W3029127048 title "Curative effects of three-dimensional conformal radiotherapy on advanced non-small cell lung cancer and the related factors of lung injury" @default.
- W3029127048 doi "https://doi.org/10.3760/cma.j.issn.1674-4756.2018.19.015" @default.
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