FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029127587> ?p ?o ?g. }

• W3029127587 endingPage "e13517" @default.
• W3029127587 startingPage "e13517" @default.
• W3029127587 abstract "e13517 Background: Kinases activated by gene fusions represent an important class of oncogenes in solid tumors highlighted by the unique site agnostic FDA approval of larotrectinib for NTRK gene rearrangements. However, the frequency and types of druggable fusions in solid tumors are not well characterized from the clinical perspective. Methods: Oncofocus is a clinically validated precision oncology platform that includes analysis of 399 druggable driver-partner oncogenic fusion genes linked to 140 unique targeted therapy protocols. A retrospective analysis of Oncofocus trending data in a real-life cohort of 1111 patients has been used to determine the actionable fusion gene landscape in solid tumors. Results: Eighty nine actionable fusion genes were identified in 1111 samples of solid tumors linked to 73 targeted therapy protocols. Seven of the samples harbored multiple fusion genes. Eighty two of the 1111 samples tested had at least one actionable fusion gene representing a frequency of 7.38%. The highest frequency of actionable fusions were observed in glioblastoma (23%), head and neck (12%), kidney (11%) and prostate (10%) cancers. Four of the seven samples with multiple actionable fusions were found in glioblastoma. Pancreatic, lung and endometrial cancers and cancer of unknown primary (CUPs) had an actionable fusion gene frequency ranging from 7-9%. TBL1XR1-PIK3CA, MET-MET, WHSC1L1-FGFR1 and EGFR VIII fusions were identified as the most common druggable fusions. All actionable fusion genes were found to interact with one or more of the following pathways RAS/RAF/MEK/ERK, PI3K/AKT/MTOR, PLCy/PKC and JAK/STAT. Although a targeted agent for TRK fusions now has FDA approval, this rearrangement appears to be a rare event. In contrast, inhibitors targeting the TBL1XR1-PIK3CA, MET-MET, WHSC1L1-FGFR1 fusions and linked downstream signalling pathways appear to offer much broader clinical utility. Conclusions: Druggable fusions were identified at an unexpectedly high frequency and should therefore be included as part of routine comprehensive precision oncology testing. Notably, many of the actionable fusions are not tumor type specific reinforcing the “site agnostic” approach to profiling and supporting the concept of “molecular basket” clinical trials. Precision oncology trending data also provides actionable mutational landscapes which can be used to refine precision oncology testing, patient selection for targeted therapy protocols and enhancement of clinical trial design." @default.
• W3029127587 created "2020-06-05" @default.
• W3029127587 creator A5009329806 @default.
• W3029127587 creator A5014625093 @default.
• W3029127587 creator A5030179927 @default.
• W3029127587 creator A5033458532 @default.
• W3029127587 creator A5038605473 @default.
• W3029127587 creator A5047236851 @default.
• W3029127587 date "2020-05-20" @default.
• W3029127587 modified "2023-10-17" @default.
• W3029127587 title "Druggable fusion gene landscape in solid tumors." @default.
• W3029127587 doi "https://doi.org/10.1200/jco.2020.38.15_suppl.e13517" @default.
• W3029127587 hasPublicationYear "2020" @default.
• W3029127587 type Work @default.
• W3029127587 sameAs 3029127587 @default.
• W3029127587 citedByCount "0" @default.
• W3029127587 crossrefType "journal-article" @default.
• W3029127587 hasAuthorship W3029127587A5009329806 @default.
• W3029127587 hasAuthorship W3029127587A5014625093 @default.
• W3029127587 hasAuthorship W3029127587A5030179927 @default.
• W3029127587 hasAuthorship W3029127587A5033458532 @default.
• W3029127587 hasAuthorship W3029127587A5038605473 @default.
• W3029127587 hasAuthorship W3029127587A5047236851 @default.
• W3029127587 hasConcept C104317684 @default.
• W3029127587 hasConcept C10679952 @default.
• W3029127587 hasConcept C111829193 @default.
• W3029127587 hasConcept C121608353 @default.
• W3029127587 hasConcept C123894998 @default.
• W3029127587 hasConcept C126322002 @default.
• W3029127587 hasConcept C143998085 @default.
• W3029127587 hasConcept C2781230642 @default.
• W3029127587 hasConcept C40767141 @default.
• W3029127587 hasConcept C502942594 @default.
• W3029127587 hasConcept C54355233 @default.
• W3029127587 hasConcept C60644358 @default.
• W3029127587 hasConcept C71924100 @default.
• W3029127587 hasConcept C86803240 @default.
• W3029127587 hasConceptScore W3029127587C104317684 @default.
• W3029127587 hasConceptScore W3029127587C10679952 @default.
• W3029127587 hasConceptScore W3029127587C111829193 @default.
• W3029127587 hasConceptScore W3029127587C121608353 @default.
• W3029127587 hasConceptScore W3029127587C123894998 @default.
• W3029127587 hasConceptScore W3029127587C126322002 @default.
• W3029127587 hasConceptScore W3029127587C143998085 @default.
• W3029127587 hasConceptScore W3029127587C2781230642 @default.
• W3029127587 hasConceptScore W3029127587C40767141 @default.
• W3029127587 hasConceptScore W3029127587C502942594 @default.
• W3029127587 hasConceptScore W3029127587C54355233 @default.
• W3029127587 hasConceptScore W3029127587C60644358 @default.
• W3029127587 hasConceptScore W3029127587C71924100 @default.
• W3029127587 hasConceptScore W3029127587C86803240 @default.
• W3029127587 hasIssue "15_suppl" @default.
• W3029127587 hasLocation W30291275871 @default.
• W3029127587 hasOpenAccess W3029127587 @default.
• W3029127587 hasPrimaryLocation W30291275871 @default.
• W3029127587 hasRelatedWork W10666957 @default.
• W3029127587 hasRelatedWork W1226145 @default.
• W3029127587 hasRelatedWork W14057078 @default.
• W3029127587 hasRelatedWork W14282520 @default.
• W3029127587 hasRelatedWork W18972001 @default.
• W3029127587 hasRelatedWork W20170433 @default.
• W3029127587 hasRelatedWork W4962130 @default.
• W3029127587 hasRelatedWork W6444463 @default.
• W3029127587 hasRelatedWork W8859235 @default.
• W3029127587 hasRelatedWork W9856781 @default.
• W3029127587 hasVolume "38" @default.
• W3029127587 isParatext "false" @default.
• W3029127587 isRetracted "false" @default.
• W3029127587 magId "3029127587" @default.
• W3029127587 workType "article" @default.