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- W3029128471 abstract "Objective To investigate the effect of naloxone combined with ginkgo bilobate extract on the brain natriuretic peptide(BNP)and endothelin-1 (ET-1) in the plasma of patients with pulmonary heart disease.Methods Eighty patients with pulmonary heart disease were randomly divided into two groups,the control group (n =40) and the treatment group (n =40).Patients in the control group were treated with conventional treatment,while patients in the treatment group were additionaly given naloxone combined with ginkgo bilobate extract.The subjects were treated for ten days.Results Compared with the control group,the PaO2 was significantly improved (P < 0.05).PaCO2 and mPAP were more significantly reduced in the treatment group than those in the control group (P <0.05).The plasma levels of BNP and ET-1 were significantly decreased after treatment in both groups,especially in the treatment group (P < 0.05).Conclusions Naloxone combined with ginkgo bilobate extract could improve the conditions of pulmonary heart disease,which are related with the reduction of BNP and ET-1.Key words: Pulmonary heart disease; Naloxone; Ginkgo bilobate extract; Brain natriuretic peptide; Endothelin-1" @default.
- W3029128471 created "2020-06-05" @default.
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- W3029128471 date "2012-11-25" @default.
- W3029128471 modified "2023-09-27" @default.
- W3029128471 title "Effect of naloxone combined with ginkgo bilobate extract on the BNP and ET-1 in the plasma of patients with pulmonary heart disease" @default.
- W3029128471 doi "https://doi.org/10.3760/cma.j.issn.1674-4756.2012.22.016" @default.
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