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- W3029129345 endingPage "106628" @default.
- W3029129345 startingPage "106628" @default.
- W3029129345 abstract "Cancer immunotherapy has brought a great revolution in the treatment of advanced human cancer. Immune checkpoint inhibitors (ICIs) that target cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death protein 1 pathway (PD-1/PD-L1) have been widely administrated in the past years and demonstrated promising in a variety of malignancies. While some patients show benefit from ICIs, others do not respond or even develop resistance to these therapies. Among the responders, the treatments are consequently accompanied with immune-related adverse effects (irAEs), which are diverse in their effected organs, degree of severity and timing. Some of the toxicities are fatal and result in discontinuance of immunotherapy. The toxicity profile from anti-CTLA-4 to anti-PD-1/PD-L1 immunotherapies is distinct from those caused by conventional anticancer therapies, though their presentation may be similar. In order to better help clinicians recognize, monitor and manage irAEs in a growing population of cancer patients who are receiving ICI therapy, this article summarizes the FDA approved ICIs and focuses on (1) existing toxic evidence related to ICIs, (2) occurrence of irAEs, (3) factors influencing tumor responders treated with ICIs, (4) predictive biomarkers of irAEs, and (5) new potential mechanisms of resistance to ICI therapy." @default.
- W3029129345 created "2020-06-05" @default.
- W3029129345 creator A5023308455 @default.
- W3029129345 creator A5025066821 @default.
- W3029129345 creator A5057986840 @default.
- W3029129345 creator A5063208707 @default.
- W3029129345 creator A5089324682 @default.
- W3029129345 date "2020-08-01" @default.
- W3029129345 modified "2023-10-18" @default.
- W3029129345 title "Factors affecting tumor responders and predictive biomarkers of toxicities in cancer patients treated with immune checkpoint inhibitors" @default.
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