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• W3029136560 abstract "ObjectiveTo establish rabbit models of VX-2 carcinoma with pyloric obstruction and explore the curative effects and safety of Cis-diammin-odichloroplatinum (DDP) and pseudomonas aeruginosa-mannose sensitive haemagglutination (PA-MSHA) combined with continuous cycle hyperthermie intraperitoneal perfusion chemotherapy (CCHIPC) on gastric cancer with pyloric obstruction in a rabbit model.MethodsVX-2 tumor cell suspension was injected to establish the rabbit model of gastric cancer with obstruction. Forty-two rabbits were randomly divided into the control group and the treatment group. All rabbit models treatment blood routine, liver and kidney function, electrolytes detection forward, the control group rabbits were 21, give direct resection of gastric cancer; treatment group rabbits were 21, given preoperative combined with enteral and parenteral nutrition after reoperation. Records of chemotherapy combined with enteral and parenteral nutrition in the treatment of rabbit model of survival, all the rabbits died the day be abdominal and thoracic, determine the primary tumor size in the gastric antrum, pyloric obstruction degree, respectively in treatment before laparotomy, died that day to take primary lesions and metastasis lesions were, he staining, under optical microscope observed. After the death of rabbits, gastric cancer was taken in situ and metastatic tumor. The expression levels of vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) were detected by immunohistochemistry.ResultsExperimental group and control group of gastric cancer radical resection rate was 85. 5% (18/21) and 66. 7% (14/21), the experimental group was significantly higher than the control group, the difference was statistically significant (P=0.025). In the experimental group and control group, the amount of bleeding, operation time, and postoperative anastomotic leakage or duodenal fistula, bleeding, stress ulcer bleeding and intestinal obstruction were not statistically significant (P=0.253). In the treatment group, the incidence of postoperative abdominal infection, pulmonary infection and gastric paralysis was significantly lower than that of the control group (P=0.019). Compared with the control group, the degree of metastasis of abdominal cavity in the experimental group was less than that in the control group, and there was less liver metastasis and less metastatic nodules. Control group experimental peritoneal carcinomatosis index (ePCI) score was 18.00±1.55, the experimental group ePCI score was 12.00±1.79, the difference between the two groups was statistically significant (P=0.013). The abdominal adhesion score of control group was 3.67±0.52, the abdominal adhesion score of the experimental group was 1.17±0.75, and there was a significant difference between the two groups (P=0.016). The gray value of VEGF expression in the control group was 77.33±6.77, the gray value of the experimental group VEGF was 200.17±4.26, the gray value of the control group PCNA was 83.33±3.49, the gray value of the experimental group PCNA was 184.83±3.76. The difference between the two groups was statistically significant (P=0.006, 0.011).ConclusionPreoperative adjuvant DDP and PA-MSHA combined with enteral and parenteral nutrition support treatment to control the progression of gastric carcinoma and relieve pyloric obstruction has a better effect and higher safety.Key words: Cis-diammin-odichloroplatinum; Ppseudomonas aeruginosa-mannose sensitive haemagglutination; Continuous cycle hyperthermie intraperitoneal perfusion chemotherapy; Gastric cancer; Pyloric obstruction" @default.
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• W3029136560 date "2017-05-08" @default.
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• W3029136560 title "Cis-diammin-odichloroplatinum and pseudomonas aeruginosa-mannose sensitive haemagglutination combined with continuous cycle hyperthermie intraperitoneal perfusion chemotherapy in the treatment of gastric cancer with pyloric obstruction in rabbit model" @default.
• W3029136560 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2017.05.017" @default.
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