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• W3029138130 abstract "ObjectiveTo evaluate the detection of membrane neutrophil alkaline phosphatase (NAP) in diagnosis of infection in patients with acute cerebral hemorrhage.MethodsA total of 208 patients with acute cerebral hemorrhage, including 152 cases without infection (uninfected group) and 56 cases with infection (infected group), admitted in the Second Affiliated Hospital of Nantong University during January 2010 to July 2016 were enrolled, 30 healthy subjects were also enrolled in the study as control group. The peripheral blood from all subjects were collected, and the counts of white blood cell (WBC), percentage of neutrophil, serum procalcitonin (PCT) and NAP were measured. The value of above 4 indicators in diagnosing infection was determined by receiver operating characteristic (ROC) curves. ANOVA and t test were used to analyze the data, Pearson correlation was performed to analyze the correlation between NAP and PCT in infected group.ResultsThe levels of WBC, percentage of neutrophil and NAP in both infected and uninfected group were higher than those in healthy control group at admission(F=117.64, 100.69 and 425.09, all P<0.01), and the levels of WBC, PCT and NAP were also higher when infection occurred compared with those at admission in infected group (t =3.14, 34.30 and 36.39, all P<0.01) . The expression of NAP was positively correlated with PCT in infected group ( r=0.762, P<0.05). ROC curve analysis showed that the areas under the curves of NAP and PCT in diagnosis of infection were 0.875 and 0.884, respectively. When 10655.28 AB/c and 5.01mg/L were taken as cut-off values, the sensitivities of NAP and PCT in diagnosis of infection were 85.50% and 87.66%; the specificities were 90.50%和90.31%, respectively. The level of NAP in infected patients with gram-positive bacterial infections was higher than that in patients with gram-negative bacterial infections (t=6.29, P<0.01).ConclusionThe expression of NAP in patients with acute cerebral hemorrhage increases when infection occurs, which may be helpful to the clinical diagnosis of bacterial infection.Key words: Cerebral hemorrhage; Bacterial infections; Alkaline phosphatase; Neutrophil; Leukocytes; Procalcitonin" @default.
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• W3029138130 date "2016-12-28" @default.
• W3029138130 modified "2023-09-28" @default.
• W3029138130 title "Detection of membrane neutrophil alkaline phosphatase in diagnosis of infection in patients with acute cerebral hemorrhage" @default.
• W3029138130 doi "https://doi.org/10.3760/cma.j.issn.1674-2397.2016.06.007" @default.
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