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- W3029164898 abstract "目的 探讨体外循环引起的全身炎症反应和肺损伤间的相互关系.方法 32例先天性心脏病合并肺动脉高压病人,测定体外循环前后呼吸生理变化、白细胞计数、白介素(IL)-6、IL-8、脂质过氧化物和血栓素、6-酮-PGFlα的变化.结果 体外循环后肺顺应性显著下降、吸气阻力和呼气阻力、峰值压力和平台压力显著升高,P＜0.05.白细胞计数、IL-6、IL-8、脂质过氧化物和血栓素、6-酮-PGFlα在体外循环后显著升高,P＜0.01,其中IL-8与肺顺应性呈负相关,r=-0.340,P＜0.05;6-酮-PGF1α与肺顺应性呈正相关,r=0.417,P＜0.05.结论 体外循环后引起全身炎症反应和肺损伤,肺损伤程度与IL-8呈正相关,与6-酮-PGF1α呈负相关.对先天性心脏病合并肺动脉高压的病人,体外循环中使用前列环素或前列腺素E1能减轻肺损伤." @default.
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- W3029164898 date "2000-07-25" @default.
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- W3029164898 title "Lung injury and systemic inflammatory response after extracorporeal circulation" @default.
- W3029164898 doi "https://doi.org/10.3760/cma.j.issn.1001-4497.2000.04.015" @default.
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