Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029168187> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3029168187 abstract "e20508 Background: The number of therapeutic options for patients with RRMM has increased significantly. Our institute treated a series of patients with induction therapy consisting of DPd followed by HDCT/ASCT. We present the early outcomes of these patients. Methods: We treated 16 patients with RRMM at the University of Kansas Health System between May 2016 and October 2019, with DPd as induction therapy followed by HDCT/ASCT. DPd was administered as Daratumumab 16 mg/kg weekly for cycles 1 and 2, every 2 weeks for cycles 3-6, and then every 4 weeks; pomalidomide was dosed at 4 mg orally on days 1-21 of a 28-day cycle; and dexamethasone 20 or 40 mg weekly. Responses were evaluated using the 2016 International Myeloma Working Group (IMWG) criteria. Results: Patients had received a median of two prior regimens. Out of the 16 patients: 81% received ASCT prior to this treatment. In addition, 75%,81% and 68% were refractory to proteasome inhibitors (PI), immunomodulatory agents (IMiDs), and double refractory to IMiDs and PI, respectively. Median time from diagnosis to treatment was 12 months. Median number of DPd cycles received was 4 cycles. A median follow-up of 27 (9-39) months, the overall response rate (ORR) after induction treatment with DPd was 100%. ORR on day 100 post ASCT was 100%, 65% achieved ≥CR, and 81% achieved ≥VGPR. There was no treatment related mortality on day 100. Median progression free survival was 34 months (95%, CI = NA), median overall survival was not reached. The most common grade ≥ 3 adverse events were thrombocytopenia 53%, anemia 40%, neutropenia 53%. Conclusions: DPd as induction therapy followed by HDCT/ASCT demonstrated deep, durable, and clinically meaningful responses with manageable safety profile in patients with RRMM. [Table: see text]" @default.
- W3029168187 created "2020-06-05" @default.
- W3029168187 creator A5008376636 @default.
- W3029168187 creator A5015261180 @default.
- W3029168187 creator A5025325121 @default.
- W3029168187 creator A5030746256 @default.
- W3029168187 creator A5039680248 @default.
- W3029168187 creator A5040104069 @default.
- W3029168187 creator A5045487042 @default.
- W3029168187 creator A5052064208 @default.
- W3029168187 creator A5086416022 @default.
- W3029168187 date "2020-05-20" @default.
- W3029168187 modified "2023-10-14" @default.
- W3029168187 title "Outcomes of daratumumab, pomalidomide, and dexamethasone (DPd) followed by high-dose chemotherapy and autologous stem cell transplantation (HDCT/ASCT) in patients with relapsed/refractory myeloma RRMM." @default.
- W3029168187 doi "https://doi.org/10.1200/jco.2020.38.15_suppl.e20508" @default.
- W3029168187 hasPublicationYear "2020" @default.
- W3029168187 type Work @default.
- W3029168187 sameAs 3029168187 @default.
- W3029168187 citedByCount "0" @default.
- W3029168187 crossrefType "journal-article" @default.
- W3029168187 hasAuthorship W3029168187A5008376636 @default.
- W3029168187 hasAuthorship W3029168187A5015261180 @default.
- W3029168187 hasAuthorship W3029168187A5025325121 @default.
- W3029168187 hasAuthorship W3029168187A5030746256 @default.
- W3029168187 hasAuthorship W3029168187A5039680248 @default.
- W3029168187 hasAuthorship W3029168187A5040104069 @default.
- W3029168187 hasAuthorship W3029168187A5045487042 @default.
- W3029168187 hasAuthorship W3029168187A5052064208 @default.
- W3029168187 hasAuthorship W3029168187A5086416022 @default.
- W3029168187 hasConcept C121332964 @default.
- W3029168187 hasConcept C126322002 @default.
- W3029168187 hasConcept C126894567 @default.
- W3029168187 hasConcept C141071460 @default.
- W3029168187 hasConcept C142424586 @default.
- W3029168187 hasConcept C143998085 @default.
- W3029168187 hasConcept C2776063141 @default.
- W3029168187 hasConcept C2776364478 @default.
- W3029168187 hasConcept C2777478702 @default.
- W3029168187 hasConcept C2778524551 @default.
- W3029168187 hasConcept C2779050716 @default.
- W3029168187 hasConcept C2780108899 @default.
- W3029168187 hasConcept C2780401358 @default.
- W3029168187 hasConcept C2781098529 @default.
- W3029168187 hasConcept C2781119759 @default.
- W3029168187 hasConcept C71924100 @default.
- W3029168187 hasConcept C87355193 @default.
- W3029168187 hasConceptScore W3029168187C121332964 @default.
- W3029168187 hasConceptScore W3029168187C126322002 @default.
- W3029168187 hasConceptScore W3029168187C126894567 @default.
- W3029168187 hasConceptScore W3029168187C141071460 @default.
- W3029168187 hasConceptScore W3029168187C142424586 @default.
- W3029168187 hasConceptScore W3029168187C143998085 @default.
- W3029168187 hasConceptScore W3029168187C2776063141 @default.
- W3029168187 hasConceptScore W3029168187C2776364478 @default.
- W3029168187 hasConceptScore W3029168187C2777478702 @default.
- W3029168187 hasConceptScore W3029168187C2778524551 @default.
- W3029168187 hasConceptScore W3029168187C2779050716 @default.
- W3029168187 hasConceptScore W3029168187C2780108899 @default.
- W3029168187 hasConceptScore W3029168187C2780401358 @default.
- W3029168187 hasConceptScore W3029168187C2781098529 @default.
- W3029168187 hasConceptScore W3029168187C2781119759 @default.
- W3029168187 hasConceptScore W3029168187C71924100 @default.
- W3029168187 hasConceptScore W3029168187C87355193 @default.
- W3029168187 hasLocation W30291681871 @default.
- W3029168187 hasOpenAccess W3029168187 @default.
- W3029168187 hasPrimaryLocation W30291681871 @default.
- W3029168187 hasRelatedWork W10198250 @default.
- W3029168187 hasRelatedWork W14748329 @default.
- W3029168187 hasRelatedWork W16896924 @default.
- W3029168187 hasRelatedWork W20936464 @default.
- W3029168187 hasRelatedWork W3657330 @default.
- W3029168187 hasRelatedWork W7211030 @default.
- W3029168187 hasRelatedWork W8713393 @default.
- W3029168187 hasRelatedWork W8870890 @default.
- W3029168187 hasRelatedWork W9899198 @default.
- W3029168187 hasRelatedWork W21064296 @default.
- W3029168187 isParatext "false" @default.
- W3029168187 isRetracted "false" @default.
- W3029168187 magId "3029168187" @default.
- W3029168187 workType "article" @default.