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- W3029188855 endingPage "595" @default.
- W3029188855 startingPage "595" @default.
- W3029188855 abstract "Pericentric heterochromatin (PCH) is a particular form of constitutive heterochromatin that is localized to both sides of centromeres and that forms silent compartments enriched in repressive marks. These genomic regions contain species-specific repetitive satellite DNA that differs in terms of nucleotide sequences and repeat lengths. In spite of this sequence diversity, PCH is involved in many biological phenomena that are conserved among species, including centromere function, the preservation of genome integrity, the suppression of spurious recombination during meiosis, and the organization of genomic silent compartments in the nucleus. PCH organization and maintenance of its repressive state is tightly regulated by a plethora of factors, including enzymes (e.g., DNA methyltransferases, histone deacetylases, and histone methyltransferases), DNA and histone methylation binding factors (e.g., MECP2 and HP1), chromatin remodeling proteins (e.g., ATRX and DAXX), and non-coding RNAs. This evidence helps us to understand how PCH organization is crucial for genome integrity. It then follows that alterations to the molecular signature of PCH might contribute to the onset of many genetic pathologies and to cancer progression. Here, we describe the most recent updates on the molecular mechanisms known to underlie PCH organization and function." @default.
- W3029188855 created "2020-06-05" @default.
- W3029188855 creator A5009564121 @default.
- W3029188855 creator A5050946363 @default.
- W3029188855 creator A5064019327 @default.
- W3029188855 creator A5081708185 @default.
- W3029188855 creator A5090615171 @default.
- W3029188855 date "2020-05-28" @default.
- W3029188855 modified "2023-10-17" @default.
- W3029188855 title "Epigenetic Factors that Control Pericentric Heterochromatin Organization in Mammals" @default.
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