Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029200073> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W3029200073 endingPage "586" @default.
- W3029200073 startingPage "582" @default.
- W3029200073 abstract "Objective To study the effects of decoy strategy targeted to NF-KB on the development of trauma-associated liver inflammation in rats. Methods In this study, 108 Wistar rats were randomized into 3 groups: control group, traumatic inflammation group and traumatic inflammation plus decoy ODN group. Rats were sacrificed on 3,6,12,24,48 and 72hrs in each group respectively. Liver functions and structural changes were examined and compared between the groups. DNA binding activity of NF-KB in liver tissue was measured by EMSA. TNF-α and IL-6 gene expressin in liver tissue was assessed by RT-PCR and TNF-α and IL-6 protein level was determined by ELISA. Results The DNA binding activity of NF-kB in liver rose at 3 hours after induction of liver inflammation following trauma and peaked at 12 hours. Correspondingly, both the mRNA and protein levels of TNF-α and IL-6 elevated significantly, as well as the serum alanine aminotransferase level culminating at 24 hours after surgery. Hepatocytes was edematous, degeneration and necrosis, with dramatic destruction of lobular structures. All these changes were significantly inhibited with NF-KB decoy oligodeoxynucleotides. Conclusions Decoy oligodeoxynucleotides specifically inhibit the activity of NF-kB, and the release of pro-inflammatory cytokines, TNF-α and IL-6 release from the liver in response to traumatic inflammation decrease, hence the injury on liver structures and functions were alleviated. Key words: Wounds and injuries; Inflammation mediators; Animals; laboratory" @default.
- W3029200073 created "2020-06-05" @default.
- W3029200073 creator A5001668691 @default.
- W3029200073 creator A5002458192 @default.
- W3029200073 creator A5014979883 @default.
- W3029200073 creator A5030228661 @default.
- W3029200073 creator A5033475332 @default.
- W3029200073 creator A5044026422 @default.
- W3029200073 creator A5049474495 @default.
- W3029200073 creator A5086331608 @default.
- W3029200073 date "2009-07-25" @default.
- W3029200073 modified "2023-09-23" @default.
- W3029200073 title "Effects of decoy strategy targeted to NF-κB on trauma-associated liver inflammation in rats" @default.
- W3029200073 doi "https://doi.org/10.3760/cma.j.issn.1007-631x.2009.07.021" @default.
- W3029200073 hasPublicationYear "2009" @default.
- W3029200073 type Work @default.
- W3029200073 sameAs 3029200073 @default.
- W3029200073 citedByCount "0" @default.
- W3029200073 crossrefType "journal-article" @default.
- W3029200073 hasAuthorship W3029200073A5001668691 @default.
- W3029200073 hasAuthorship W3029200073A5002458192 @default.
- W3029200073 hasAuthorship W3029200073A5014979883 @default.
- W3029200073 hasAuthorship W3029200073A5030228661 @default.
- W3029200073 hasAuthorship W3029200073A5033475332 @default.
- W3029200073 hasAuthorship W3029200073A5044026422 @default.
- W3029200073 hasAuthorship W3029200073A5049474495 @default.
- W3029200073 hasAuthorship W3029200073A5086331608 @default.
- W3029200073 hasConcept C126322002 @default.
- W3029200073 hasConcept C134018914 @default.
- W3029200073 hasConcept C170493617 @default.
- W3029200073 hasConcept C17991360 @default.
- W3029200073 hasConcept C203014093 @default.
- W3029200073 hasConcept C2776637226 @default.
- W3029200073 hasConcept C2776914184 @default.
- W3029200073 hasConcept C2777730290 @default.
- W3029200073 hasConcept C2779179475 @default.
- W3029200073 hasConcept C71924100 @default.
- W3029200073 hasConceptScore W3029200073C126322002 @default.
- W3029200073 hasConceptScore W3029200073C134018914 @default.
- W3029200073 hasConceptScore W3029200073C170493617 @default.
- W3029200073 hasConceptScore W3029200073C17991360 @default.
- W3029200073 hasConceptScore W3029200073C203014093 @default.
- W3029200073 hasConceptScore W3029200073C2776637226 @default.
- W3029200073 hasConceptScore W3029200073C2776914184 @default.
- W3029200073 hasConceptScore W3029200073C2777730290 @default.
- W3029200073 hasConceptScore W3029200073C2779179475 @default.
- W3029200073 hasConceptScore W3029200073C71924100 @default.
- W3029200073 hasIssue "07" @default.
- W3029200073 hasLocation W30292000731 @default.
- W3029200073 hasOpenAccess W3029200073 @default.
- W3029200073 hasPrimaryLocation W30292000731 @default.
- W3029200073 hasRelatedWork W2000660334 @default.
- W3029200073 hasRelatedWork W2048439300 @default.
- W3029200073 hasRelatedWork W2086095338 @default.
- W3029200073 hasRelatedWork W2361124578 @default.
- W3029200073 hasRelatedWork W2375394079 @default.
- W3029200073 hasRelatedWork W2381763479 @default.
- W3029200073 hasRelatedWork W2386712049 @default.
- W3029200073 hasRelatedWork W2389305767 @default.
- W3029200073 hasRelatedWork W2392987404 @default.
- W3029200073 hasRelatedWork W2401514197 @default.
- W3029200073 hasRelatedWork W2756717259 @default.
- W3029200073 hasRelatedWork W2772559090 @default.
- W3029200073 hasRelatedWork W2965209357 @default.
- W3029200073 hasRelatedWork W2966962053 @default.
- W3029200073 hasRelatedWork W3025874136 @default.
- W3029200073 hasRelatedWork W3045452192 @default.
- W3029200073 hasRelatedWork W3102391728 @default.
- W3029200073 hasRelatedWork W3158043153 @default.
- W3029200073 hasRelatedWork W3166170310 @default.
- W3029200073 hasRelatedWork W3191009247 @default.
- W3029200073 hasVolume "24" @default.
- W3029200073 isParatext "false" @default.
- W3029200073 isRetracted "false" @default.
- W3029200073 magId "3029200073" @default.
- W3029200073 workType "article" @default.