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- W3029207710 abstract "ObjectiveTo explore the influence of epidural analgesia on stress, immune and survival in patients with ovarian cancer undergoing cytoreductive surgery.Methods72 cases with ovarian cancer undergoing cytoreductive surgery were divided into group A and group B according to random number table method. Patients in group A were treated with epidural analgesia, while patients in group B were treated with intravenous analgesia. The stress index, the plasma cortisol and immune indexes, CD3+, CD4+, CD8+ and CD4+/CD8+ at 30 mins before surgery (T1) , right after surgery (T2) , 12 h after surgery (T3) , 1 d after surgery (T4) and 3 d after surgery (T5) between the two groups were observed. The overall survival and free survival in the two groups were compared.ResultsThe plasma cortisol levels was lower in group A than in group B (Fgroup=27.784, P=0.000) . The plasma cortisol levels in the two groups increased first and then decreased (Ftime=109.268, P=0.000) , and the decrease rate in group A was higher than that in group B (Finteraction=22.092, P=0.000) . The levels of CD3+, CD4+ and CD4+/CD8+ were higher in group A than in group B, while the level of CD8+ was lower in group A than in group B (Fgroup=5.893, 6.110, 7.283, 5.593, P 0.05) .ConclusionEpidural analgesia may reduce the stress response in patients with ovarian cancer undergoing cytoreductive surgery, and protect the immune function, but the influence on survival is not obvious.Key words: Epidural analgesia; Cytoreductive surgery; Ovarian cancer; Stress; Immune; Survival" @default.
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- W3029207710 date "2017-04-25" @default.
- W3029207710 modified "2023-09-28" @default.
- W3029207710 title "The influence of epidural analgesia on stress, immune and survival in patients with ovarian cancer undergoing cytoreductive surgery" @default.
- W3029207710 doi "https://doi.org/10.3760/cma.j.issn.1674-6090.2017.02.012" @default.
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