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- W3029219991 abstract "Classical breakpoint cluster region/Abelson leukemia virus (BCR/ABL) fusion gene negative myeloproliferative neoplasms (MPN),including polycythemia vera (PV),essential thrombocythemia (ET) and primary myelofibrosis (PMF),are malignant myeloproliferative disorders which originated from pluripotent hematopoietic stem cells.Recently,a number of studies showed somatic calreticulin (CALR) gene mutation was found in a majority of patients diagnosed as Janus kinase (JAK)2 mutation-negative MPN.This article reviews the literatures on the pathogenesis,clinical manifestation and diagnosis of MPN with CALR mutation.Key words: Calreticulin; Genes; Mutation; Myeloproliferative neoplasms; Janus kinase 2" @default.
- W3029219991 created "2020-06-05" @default.
- W3029219991 creator A5059220012 @default.
- W3029219991 date "2014-11-20" @default.
- W3029219991 modified "2023-09-24" @default.
- W3029219991 title "Advances of CALR Gene Mutation in Myeloproliferative Neoplasms" @default.
- W3029219991 doi "https://doi.org/10.3760/cma.j.issn.1673-419x.2014.06.014" @default.
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