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• W3029221336 abstract "Objective To explore the effects of aberrant methylation in the CDH1,GSTP1 and RASSF1A gene promoter CpG region and lymphocyte micronucleus on the pathogenesis of hepatocellular carcinoma(HCC).Methods The methylation-specific polymerase chain reaction(MSP)was employed to investigate the promoter methylation of CDH1,GSTP1 and RASSF1A genes in the tumor and adjacent tissues in 32 patients with HCC.The peripheral blood was sampled from patients with HCC for subsequent micronucleus test for lymphocytes,prior to the treatment.The differences of the spontaneous micronucleus rate in HCC patients and healthy population control group(n=50) were compared.Results Tumor tissues of patients with HCC yielded higher assay sensitivity for detection of methylation of CDH1,GSTP1 and RASSF1A genes[43.8％(14/32),68.8％(22/32) and 43.8％ (14/32)] than adjacent tissues [25％ (8/32),46.9％ (15/32) and 15.6％ (5/32)].Nevertheless,the between-group difference in methylation for various genes did not reach statistical significance with exception of RASSF1A gene(43.8％ vs 15.6％,P＜0.05).Methylation in one or more of the three genes was noted in tumor tissues[81.3％(26/32)] and adjacent tissues[65.6％(21/32)].Additionally,the status of methylation was not statistically associated with the age,sex,type of tumor and tumor differentiation.Patients with HCC,who showed a raised risk of automatic micronucleation with the advanced pathologic differentiation,were featured by a higher rate of micronucleation when compared with normal controls(1.38‰ vs 0.47‰,P＜0.05).The frequency of micronucleation was 1.30‰,1.33‰ and 1.64‰o in patients with moderate-to-high,moderate and low differentiation of HCC.Conclusions Genetic instability and promoter methylation of CDH1,GSTP1 and RASSF1A genes may play a vital role in the pathogenesis of HCC.Early stage HCC may be closely linked to aberrant promoter region methylation.Methylation detection is valuable in screening high-risk population and establishing adjunct early diagnosis of HCC.Key words: Carcinoma,hepatocellular; CDH1; Glutathione S-transferase pi; RASSF1A; DNA methylation; Micronucleus tests" @default.
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• W3029221336 date "2013-02-15" @default.
• W3029221336 modified "2023-09-22" @default.
• W3029221336 title "Effects of DNA methylation and micronucleus formation on pathogenesis of hepatocellular carcinoma by methylation-specific polymerase chain reaction and microscopy" @default.
• W3029221336 doi "https://doi.org/10.3760/cma.j.issn.1674-1927.2013.01.003" @default.
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