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- W3029232012 abstract "ObjectiveBy studying the levels of nestin and MAP-2 in patients with schizophrenia, to explore the intrinsic pathogenesis of schizophrenia and to find more intervention and treatment methods for the disease.Methods60 patients with first episode schizophrenia admitted to our hospital from March, 2018 to March, 2019 were selected as a case group, and 60 healthy volunteers who underwent community physical examination during the same period were randomly selected as a control group. There were 34 male and 26 female in the case group; and they were (36.38±9.18) years old. There were 35 male and 25 female in the control group; and they were (35.28±7.81) years old. The nestin and MAP-2 in both groups were detected. The control group were treated with risperidone tablets. Before and 6 weeks and 6 months after the treatment, the nestin and MAP-2 in the case group were detected, and compared with those of the control group. Positive and negative symptom scale (PANSS) was used to measure the patients before and 6 weeks after the treatment, and the efficacies before and after the treatment were compared.ResultsThe levels of nestin and MAP-2 in the case group were significantly lower than those in the control group (both P 0.05). The PANSS score was significantly lower after than before the treatment in the case group (P<0.01). The correlation analysis suggested that nestin and MAP-2 levels were negatively correlated with the degree of schizophrenia symptoms (both P<0.01).ConclusionNestin and MAP-2 can be used as important biochemical indicators in the evaluation of the efficacy of early intervention and treatment for schizophrenia.Key words: Nestin; MAP-2; Schizophrenia" @default.
- W3029232012 created "2020-06-05" @default.
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- W3029232012 date "2020-02-15" @default.
- W3029232012 modified "2023-09-23" @default.
- W3029232012 title "Changes of nestin and MAP-2 in blood of patients with first-episode schizophrenia treated by risperidone" @default.
- W3029232012 doi "https://doi.org/10.3760/cma.j.issn.1007-1245.2020.04.010" @default.
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