FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029251296> ?p ?o ?g. }

• W3029251296 abstract "Gene expression alterations have been implicated in suicide pathology. However, the study of the regulatory effect of DNA methylation on gene expression in the suicidal brain has been restricted to candidate genes.The objective of the study was to identify genes whose expression levels are correlated with DNA methylation in the prefrontal cortex of suicides.Postmortem prefrontal cortex samples from 21 suicides and six non-suicides were collected. Transcriptomic and DNA methylation profiles were evaluated with microarrays; cis correlations between gene expression and CpG methylation were screened. We then analyzed the presence of transcription factor (TF) binding sites (TFBS) at CpG sites correlated with gene expression. Gene expression of TFs involved in neurodevelopmental binding to predicted TFBS was determined in the BrainSpan database.We identified 22 CpG sites whose methylation levels correlated with gene expression in the prefrontal cortex of suicides. Genes annotated to identified CpG sites were involved in neurodevelopment (BBS4, NKX6-2, AXL, CTNND1, and MBP) and polyamine metabolism (polyamine oxidase [PAOX]). Such correlations were not detected in the nonsuicide group. Nine TFs (USF1, TBP, SF1, NRF1, RFX1, SP3, PKNOX1, MAZ, and POU3F2) showed differential expression in pre- and post-natal developmental periods, according to BrainSpan database.The integration of different omic technologies provided novel candidates for the investigation of genes whose expression is altered in the suicidal brain and their potential regulatory mechanisms." @default.
• W3029251296 created "2020-06-05" @default.
• W3029251296 creator A5000708662 @default.
• W3029251296 creator A5012752153 @default.
• W3029251296 creator A5013581165 @default.
• W3029251296 creator A5013687245 @default.
• W3029251296 creator A5028287374 @default.
• W3029251296 creator A5040743896 @default.
• W3029251296 creator A5059238828 @default.
• W3029251296 creator A5072275864 @default.
• W3029251296 creator A5072950865 @default.
• W3029251296 creator A5080833451 @default.
• W3029251296 creator A5085862348 @default.
• W3029251296 date "2021-02-01" @default.
• W3029251296 modified "2023-09-24" @default.
• W3029251296 title "Brain Gene Expression-DNA Methylation Correlation in Suicide Completers: Preliminary Results" @default.
• W3029251296 cites W123624321 @default.
• W3029251296 cites W1970234726 @default.
• W3029251296 cites W1975528145 @default.
• W3029251296 cites W1982232439 @default.
• W3029251296 cites W1993761459 @default.
• W3029251296 cites W1995493368 @default.
• W3029251296 cites W2000551557 @default.
• W3029251296 cites W2003586939 @default.
• W3029251296 cites W2013444425 @default.
• W3029251296 cites W2014414194 @default.
• W3029251296 cites W2017676016 @default.
• W3029251296 cites W2019203176 @default.
• W3029251296 cites W2022809747 @default.
• W3029251296 cites W2024518588 @default.
• W3029251296 cites W2029442436 @default.
• W3029251296 cites W2040422645 @default.
• W3029251296 cites W2055113972 @default.
• W3029251296 cites W2058166388 @default.
• W3029251296 cites W2073023785 @default.
• W3029251296 cites W2075363163 @default.
• W3029251296 cites W2083225762 @default.
• W3029251296 cites W2085361495 @default.
• W3029251296 cites W2100697281 @default.
• W3029251296 cites W2101870168 @default.
• W3029251296 cites W2108573302 @default.
• W3029251296 cites W2110065044 @default.
• W3029251296 cites W2116102471 @default.
• W3029251296 cites W2125115422 @default.
• W3029251296 cites W2127938920 @default.
• W3029251296 cites W2128016314 @default.
• W3029251296 cites W2130080387 @default.
• W3029251296 cites W2133465414 @default.
• W3029251296 cites W2139676627 @default.
• W3029251296 cites W2148337554 @default.
• W3029251296 cites W2158217645 @default.
• W3029251296 cites W2159379246 @default.
• W3029251296 cites W2167037755 @default.
• W3029251296 cites W2494121918 @default.
• W3029251296 cites W2562306774 @default.
• W3029251296 cites W2610903912 @default.
• W3029251296 cites W2888365139 @default.
• W3029251296 cites W2967286825 @default.
• W3029251296 cites W91124670 @default.
• W3029251296 doi "https://doi.org/10.24875/ric.19003250" @default.
• W3029251296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33057323" @default.
• W3029251296 hasPublicationYear "2021" @default.
• W3029251296 type Work @default.
• W3029251296 sameAs 3029251296 @default.
• W3029251296 citedByCount "3" @default.
• W3029251296 countsByYear W30292512962021 @default.
• W3029251296 countsByYear W30292512962023 @default.
• W3029251296 crossrefType "journal-article" @default.
• W3029251296 hasAuthorship W3029251296A5000708662 @default.
• W3029251296 hasAuthorship W3029251296A5012752153 @default.
• W3029251296 hasAuthorship W3029251296A5013581165 @default.
• W3029251296 hasAuthorship W3029251296A5013687245 @default.
• W3029251296 hasAuthorship W3029251296A5028287374 @default.
• W3029251296 hasAuthorship W3029251296A5040743896 @default.
• W3029251296 hasAuthorship W3029251296A5059238828 @default.
• W3029251296 hasAuthorship W3029251296A5072275864 @default.
• W3029251296 hasAuthorship W3029251296A5072950865 @default.
• W3029251296 hasAuthorship W3029251296A5080833451 @default.
• W3029251296 hasAuthorship W3029251296A5085862348 @default.
• W3029251296 hasBestOaLocation W30292512961 @default.
• W3029251296 hasConcept C104317684 @default.
• W3029251296 hasConcept C140173407 @default.
• W3029251296 hasConcept C150194340 @default.
• W3029251296 hasConcept C153911025 @default.
• W3029251296 hasConcept C162317418 @default.
• W3029251296 hasConcept C165864922 @default.
• W3029251296 hasConcept C169760540 @default.
• W3029251296 hasConcept C169900460 @default.
• W3029251296 hasConcept C190727270 @default.
• W3029251296 hasConcept C2781195155 @default.
• W3029251296 hasConcept C33288867 @default.
• W3029251296 hasConcept C41091548 @default.
• W3029251296 hasConcept C54355233 @default.
• W3029251296 hasConcept C86803240 @default.
• W3029251296 hasConcept C95371953 @default.
• W3029251296 hasConceptScore W3029251296C104317684 @default.
• W3029251296 hasConceptScore W3029251296C140173407 @default.
• W3029251296 hasConceptScore W3029251296C150194340 @default.
• W3029251296 hasConceptScore W3029251296C153911025 @default.
• W3029251296 hasConceptScore W3029251296C162317418 @default.

• next