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- W3029256557 abstract "ObjectiveTo observe the efficacy of duloxetine combined with Bodhi Tree relaxation technique in the treatment of generalized anxiety disorder(GAD) and the influence of heart rate variability(HRV).MethodsAccording to the standard of ICD-10, 124 GADs were selected as study objects from March 2013 to March 2014. They were randomly divided into intervention group and control group. The intervention group fixedly received duloxetine (20 mg/day) and Bodhi Tree relaxation therapy, 2 times / week, for 8 weeks; and the control group received only Duloxetine (20 mg/day) treatment. All patients were assessed with SAS, HAMA and Treatment Emergent Symptom Scale(TESS) at the baseline and at the end of the 2nd, 4th, 6th, 8th week of the treatment to evaluate the efficacy and side effects. The LF/HF of HRV were observed.Results1.In both groups, SAS score and HAMA score remarkably decreased after intervention than before treatment(before intervention: control group(63.52±14.25, 30.26±11.25) intervention group (64.35±14.33, 29.83±10.85); after 8 weeks: control group(30.23±6.68, 9.28±3.20) intervention group (25.14±5.59, 7.70±2.87), P 0.05). 2. The ratio of LF/HF showed significantly decrease in the intervention group than those in the control groupt13-16=-2.806, -2.725, -3.572, -2.272; P13-16=0.006, 0.007, 0.001, 0.025). The value of anxiety severity index and LF/HF was positively correlated (r=0.342, P<0.05).ConclusionDuloxetine combined with Bodhi Tree relaxation technique can effectively improve the heart rate variability in patients, curative effect is better.Key words: Duloxetine; Bodhi Tree relaxation technique; Generalized anxiety disorder; Heart rate variability" @default.
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- W3029256557 date "2014-11-20" @default.
- W3029256557 modified "2023-09-24" @default.
- W3029256557 title "Efficacy of duloxetine combined with Bodhi Tree relaxation technique in the treatment of the generalized anxiety disorder and influence of heart rate variability" @default.
- W3029256557 doi "https://doi.org/10.3760/cma.j.issn.1674-6554.2014.11.013" @default.
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