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- W3029261582 abstract "ObjectiveTo investigate the effect of Danshen injection combined with extended release nifedipine tablets on gestational hypertension.Methods200 patients with gestational hypertension in our hospital from March 2014 to March 2016 were selected, and randomly divided into observation group (100 cases) and control group (100 cases). Control group received extended release nifedipine tablets treatment, and observation group received Danshen injection treatment on the basis of control group. The treatment lasted for two weeks. The treatment effect, blood pressure, vascular endothelial function, thrombin indexes before and after treatment, adverse reactions, and pregnancy outcome were compared between two groups.ResultsThe total efficiency of observation group was higher than that of control group (P<0.05); systolic and diastolic blood pressure of observation group after treatment were lower than those of control group (P<0.05); the level of ET-1 of observation group after treatment was lower than that of control group, the level of NO was higher than that of control group (P<0.05); the levels of thrombin indexes (fibrinogen, PT, APTT) of observation group after treatment were lower than those of control group (P<0.05); electrocardiogram, blood, urine, liver and kidney functions were normal in two groups, without significant adverse drug reactions; the rates of cesarean section and abnormal fetal heart of observation group were lower than those of control group (P<0.05).ConclusionDanshen injection combined with extended release nifedipine tablets has significant effect on gestational hypertensive patients, which may be related to decreasing blood pressure, improving vascular endothelial function and thrombin indexes, can reduce the incidence of adverse pregnancy outcomes.Key words: Danshen injection; Extended release nifedipine tablets; Gestational hypertension; Curative effect" @default.
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- W3029261582 date "2017-02-15" @default.
- W3029261582 modified "2023-09-23" @default.
- W3029261582 title "Effect observation of Danshen injection combined with extended release nifedipine tablets on gestational hypertension" @default.
- W3029261582 doi "https://doi.org/10.3760/cma.j.issn.1007-1245.2017.04.032" @default.
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