FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029267490> ?p ?o ?g. }

• W3029267490 endingPage "41" @default.
• W3029267490 startingPage "27" @default.
• W3029267490 abstract "AbstractImmunofluorescence allows the detection, visualization, and localization of proteins by using the ability of antibodies to firmly bind to specific antigens. Proteins must be accessible to thorough interaction with the specific antibodies. Different immune evasion mechanisms of parasites are directed to hamper or prevent access of antibodies to critical proteins or virulence factors. The blood fluke Schistosoma mansoni would not survive a day in the host blood capillaries if antibodies were able to readily bind to proteins located at the surface and mediate its attrition and demise by the complement system and/or the FcγR- or FcαR-bearing leukocytes. The worm surface is the area of parasite-host interaction and the route to critical nutrients, but is selectively permeable, allowing access of nutrient molecules but not host antibodies. Gentle procedures, which, however, are not commonly in use in vivo, are required to increase the permeability of the parasite outer membrane shield to just allow access of specific antibodies and identify and localize the proteins at the apical surface. Robust methods involving acetone, methanol, and Triton X-100 treatment lead to disintegration of the dual lipid bilayer cover with exposure of the proteins located in the tegument beneath. Internal proteins may not be accessed except following cryostat or paraffin sectioning. Accordingly, vaccine-induced specific antibodies to the apical surface or tegument proteins are unable to harm intact parasites. Specific antibodies to surface membrane proteins may only add to the action of administered or endo schistosomicides via acceleration of killing and interference with repair of severely and lightly impacted parasites, respectively. Therefore, careful immunofluorescent localization of S. mansoni proteins is important for devising the different control strategies against infection.Key words Schistosoma mansoni Immunofluorescence Sphingomyelin Hydrogen bond barrier Apical membrane antigens Tegumental antigens Cytosolic antigens" @default.
• W3029267490 created "2020-06-05" @default.
• W3029267490 creator A5007399225 @default.
• W3029267490 creator A5040944698 @default.
• W3029267490 date "2020-01-01" @default.
• W3029267490 modified "2023-09-27" @default.
• W3029267490 title "Immunofluorescent Localization of Proteins in Schistosoma mansoni" @default.
• W3029267490 cites W1549521886 @default.
• W3029267490 cites W1926531442 @default.
• W3029267490 cites W1967499606 @default.
• W3029267490 cites W1976147671 @default.
• W3029267490 cites W1978701936 @default.
• W3029267490 cites W1989613338 @default.
• W3029267490 cites W1992237747 @default.
• W3029267490 cites W1998550541 @default.
• W3029267490 cites W2008428396 @default.
• W3029267490 cites W2009633750 @default.
• W3029267490 cites W2015928161 @default.
• W3029267490 cites W2021169613 @default.
• W3029267490 cites W2025268916 @default.
• W3029267490 cites W2026780245 @default.
• W3029267490 cites W2033627745 @default.
• W3029267490 cites W2040469495 @default.
• W3029267490 cites W2055474759 @default.
• W3029267490 cites W2057596265 @default.
• W3029267490 cites W2065196424 @default.
• W3029267490 cites W2066318157 @default.
• W3029267490 cites W2067515857 @default.
• W3029267490 cites W2074537157 @default.
• W3029267490 cites W2075902995 @default.
• W3029267490 cites W2077116963 @default.
• W3029267490 cites W2085075048 @default.
• W3029267490 cites W2085265412 @default.
• W3029267490 cites W2088322415 @default.
• W3029267490 cites W2097979284 @default.
• W3029267490 cites W2106526347 @default.
• W3029267490 cites W2117660295 @default.
• W3029267490 cites W2127426406 @default.
• W3029267490 cites W2153871510 @default.
• W3029267490 cites W2161796698 @default.
• W3029267490 cites W2164453477 @default.
• W3029267490 cites W2185123359 @default.
• W3029267490 cites W2463756368 @default.
• W3029267490 cites W2762169577 @default.
• W3029267490 cites W2763029673 @default.
• W3029267490 cites W2807216936 @default.
• W3029267490 cites W2809043543 @default.
• W3029267490 cites W2843374596 @default.
• W3029267490 cites W2895421104 @default.
• W3029267490 cites W2899665503 @default.
• W3029267490 cites W2914867316 @default.
• W3029267490 cites W2595322532 @default.
• W3029267490 doi "https://doi.org/10.1007/978-1-0716-0635-3_3" @default.
• W3029267490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32451993" @default.
• W3029267490 hasPublicationYear "2020" @default.
• W3029267490 type Work @default.
• W3029267490 sameAs 3029267490 @default.
• W3029267490 citedByCount "2" @default.
• W3029267490 countsByYear W30292674902021 @default.
• W3029267490 countsByYear W30292674902022 @default.
• W3029267490 crossrefType "book-chapter" @default.
• W3029267490 hasAuthorship W3029267490A5007399225 @default.
• W3029267490 hasAuthorship W3029267490A5040944698 @default.
• W3029267490 hasConcept C144647389 @default.
• W3029267490 hasConcept C146998594 @default.
• W3029267490 hasConcept C147483822 @default.
• W3029267490 hasConcept C159047783 @default.
• W3029267490 hasConcept C159654299 @default.
• W3029267490 hasConcept C165901193 @default.
• W3029267490 hasConcept C203014093 @default.
• W3029267490 hasConcept C2776225656 @default.
• W3029267490 hasConcept C2776863245 @default.
• W3029267490 hasConcept C41625074 @default.
• W3029267490 hasConcept C55493867 @default.
• W3029267490 hasConcept C86803240 @default.
• W3029267490 hasConcept C95444343 @default.
• W3029267490 hasConceptScore W3029267490C144647389 @default.
• W3029267490 hasConceptScore W3029267490C146998594 @default.
• W3029267490 hasConceptScore W3029267490C147483822 @default.
• W3029267490 hasConceptScore W3029267490C159047783 @default.
• W3029267490 hasConceptScore W3029267490C159654299 @default.
• W3029267490 hasConceptScore W3029267490C165901193 @default.
• W3029267490 hasConceptScore W3029267490C203014093 @default.
• W3029267490 hasConceptScore W3029267490C2776225656 @default.
• W3029267490 hasConceptScore W3029267490C2776863245 @default.
• W3029267490 hasConceptScore W3029267490C41625074 @default.
• W3029267490 hasConceptScore W3029267490C55493867 @default.
• W3029267490 hasConceptScore W3029267490C86803240 @default.
• W3029267490 hasConceptScore W3029267490C95444343 @default.
• W3029267490 hasLocation W30292674901 @default.
• W3029267490 hasOpenAccess W3029267490 @default.
• W3029267490 hasPrimaryLocation W30292674901 @default.
• W3029267490 hasRelatedWork W1965531039 @default.
• W3029267490 hasRelatedWork W2001976376 @default.
• W3029267490 hasRelatedWork W2016184765 @default.
• W3029267490 hasRelatedWork W2065548809 @default.
• W3029267490 hasRelatedWork W2098969884 @default.
• W3029267490 hasRelatedWork W2150135081 @default.

• next