Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029281378> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3029281378 endingPage "2737" @default.
- W3029281378 startingPage "2735" @default.
- W3029281378 abstract "Objective To observe the protective effect and mechanism of hydroxyethyl starch 130/ 0.4 (HES130/0.4) against early injury of hepatic ischemia/reperfusion in rats.Methods Forty female SD rats were randomly divided into 4 groups:sham operation group (Sham group),ischemia/reperfusion group (IR group),ischemia/reperfusion + 7.5％ hypertonic saline group (IR + HS group),and ischemia/reperfusion + hydroxyethyl starch group (IR + HES group),n =10 each.The rats in IR + HES group and IR + HS group were subjected to hepatic ischemia for 60 min,followed by intravenous infusion of HES 130/0.4 and 7.5％ HS (13 ml/kg),and finally 120 min of reperfusion.Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined.Superoxide dismutase (SOD),malondialdehyde (MDA) and histopathological changes in the liver tissue were examined.Results As compared with Sham group,serum ALT and AST,and liver MDA in the IR group [(481.64 ±86.32),(793.16 ± 86.51) IU/L,and (6.45 ±0.63) nmol/(mg·prot)],IR + HS group [(461.44 ±76.35),(784.58 ± 81.05) IU/L,and (6.25 ±0.69) nmol/(mg·prot)] and IR + HES group [(230.23 ±51.85),(330.14 ± 23.52) IU/L,and (5.04 ± 0.62) nmol/(mg· prot)] were significantly increased (P ＜ 0.05) ; SOD activity [(129.35 ± 17.05),(133.64 ± 16.60) and (160.25 ± 28.80) U/(mg· prot)] reduced (P＜0.05) ; liver histopathology scores were increased (P＜0.05).Conclusion HES 130/0.4 has protective effects on hepatic ischemia/reperfusion in rats,which may be related to accelerate the elimination of oxygen free radicals,and reduce oxygen free radical-mediated lipid peroxidation.Key words: Hydroxyethyl starch; Liver ischemia; Reperfusion injury; Oxygen free radicals" @default.
- W3029281378 created "2020-06-05" @default.
- W3029281378 creator A5023815240 @default.
- W3029281378 creator A5037746615 @default.
- W3029281378 creator A5064220222 @default.
- W3029281378 date "2014-12-08" @default.
- W3029281378 modified "2023-09-23" @default.
- W3029281378 title "Protective effect of hydroxyethyl starch 130/0.4 on hepatic ischemia/reperfusion injury in rat" @default.
- W3029281378 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2014.12.035" @default.
- W3029281378 hasPublicationYear "2014" @default.
- W3029281378 type Work @default.
- W3029281378 sameAs 3029281378 @default.
- W3029281378 citedByCount "0" @default.
- W3029281378 crossrefType "journal-article" @default.
- W3029281378 hasAuthorship W3029281378A5023815240 @default.
- W3029281378 hasAuthorship W3029281378A5037746615 @default.
- W3029281378 hasAuthorship W3029281378A5064220222 @default.
- W3029281378 hasConcept C126322002 @default.
- W3029281378 hasConcept C134018914 @default.
- W3029281378 hasConcept C142724271 @default.
- W3029281378 hasConcept C185592680 @default.
- W3029281378 hasConcept C2775838275 @default.
- W3029281378 hasConcept C2776151105 @default.
- W3029281378 hasConcept C2778401633 @default.
- W3029281378 hasConcept C2779412105 @default.
- W3029281378 hasConcept C2780114680 @default.
- W3029281378 hasConcept C2992872382 @default.
- W3029281378 hasConcept C42219234 @default.
- W3029281378 hasConcept C541997718 @default.
- W3029281378 hasConcept C544855455 @default.
- W3029281378 hasConcept C71924100 @default.
- W3029281378 hasConceptScore W3029281378C126322002 @default.
- W3029281378 hasConceptScore W3029281378C134018914 @default.
- W3029281378 hasConceptScore W3029281378C142724271 @default.
- W3029281378 hasConceptScore W3029281378C185592680 @default.
- W3029281378 hasConceptScore W3029281378C2775838275 @default.
- W3029281378 hasConceptScore W3029281378C2776151105 @default.
- W3029281378 hasConceptScore W3029281378C2778401633 @default.
- W3029281378 hasConceptScore W3029281378C2779412105 @default.
- W3029281378 hasConceptScore W3029281378C2780114680 @default.
- W3029281378 hasConceptScore W3029281378C2992872382 @default.
- W3029281378 hasConceptScore W3029281378C42219234 @default.
- W3029281378 hasConceptScore W3029281378C541997718 @default.
- W3029281378 hasConceptScore W3029281378C544855455 @default.
- W3029281378 hasConceptScore W3029281378C71924100 @default.
- W3029281378 hasIssue "12" @default.
- W3029281378 hasLocation W30292813781 @default.
- W3029281378 hasOpenAccess W3029281378 @default.
- W3029281378 hasPrimaryLocation W30292813781 @default.
- W3029281378 hasRelatedWork W1500776445 @default.
- W3029281378 hasRelatedWork W1594253674 @default.
- W3029281378 hasRelatedWork W2111826022 @default.
- W3029281378 hasRelatedWork W2349085002 @default.
- W3029281378 hasRelatedWork W2358405068 @default.
- W3029281378 hasRelatedWork W2362629294 @default.
- W3029281378 hasRelatedWork W2368665980 @default.
- W3029281378 hasRelatedWork W2371057815 @default.
- W3029281378 hasRelatedWork W2373715106 @default.
- W3029281378 hasRelatedWork W2375819484 @default.
- W3029281378 hasRelatedWork W2385779299 @default.
- W3029281378 hasRelatedWork W2386227562 @default.
- W3029281378 hasRelatedWork W2389814608 @default.
- W3029281378 hasRelatedWork W2408792900 @default.
- W3029281378 hasRelatedWork W3028795031 @default.
- W3029281378 hasRelatedWork W3029520685 @default.
- W3029281378 hasRelatedWork W3029838919 @default.
- W3029281378 hasRelatedWork W3030789691 @default.
- W3029281378 hasRelatedWork W139708111 @default.
- W3029281378 hasRelatedWork W2186308462 @default.
- W3029281378 hasVolume "31" @default.
- W3029281378 isParatext "false" @default.
- W3029281378 isRetracted "false" @default.
- W3029281378 magId "3029281378" @default.
- W3029281378 workType "article" @default.