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- W3029305844 abstract "目的 探讨肝细胞癌合并肝硬化患者术后应用重组人生长激素(rhGH)联合肠外营养(PN)对生长激素(GH)/胰岛素样生长因子-1(IGF-1)轴的影响.方法 24例行根治性切除的肝癌患者随机分为PN组(n=12)和rhGH+PN组(n=12).术前、术后1 d和6 d测血清GH、IGF-1、IGFBP-3,用RT-PCR法检测肝组织(包括癌组织,癌旁组织和术后6d肝穿刺组织)IGF-1 mRNA、IGFBP-3 mRNA的表达,肝组织行Ki67免疫组织化学染色.同时选12例因胆石症或肝血管瘤行手术的患者作为正常对照.结果 肝细胞癌合并肝硬化患者血清GH水平高于正常对照组,而血清IGF-1、IGFBP-3水平低于正常对照组;术后6 d,血清GH、IGF-1、IGFBP-3水平、肝组织IGF-1 mRNA、IGFBP-3 mRNA表达水平、肝Ki67指数,rhGH+PN组均高于PN组.PN组中位无瘤生存期是11.2个月,rhGH+PN组中位无瘤生存期是11.4个月;PN组6个月、12个月无瘤生存率分别是71.1%、46.2%,rhGH+PN组6个月、12个月无瘤生存率分别是72.2%、59.0%,差异均无统计学意义(P＞0.05).结论 rhGH+PN有利于改善肝细胞癌合并肝硬化患者术后GH/IGF-1轴。" @default.
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- W3029305844 title "Effect of recombinant human growth hormone combined with parenteral nutrition on growth hormone/Insulin-like growth factor-1 axis after hepatectomy in hepatocellular carcinoma with liver cirrhosis" @default.
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