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- W3029307944 abstract "ObjectiveTo evaluate the efficacy and safety of early anticoagulation therapy using low-molecular-weight heparin sodium against venous thromboembolism (VTE) in traumatic patients.MethodsA total of 120 severely traumatized patients were assigned to convention group (n=60) and anticoagulation group (n=60) according to the random number table. Patients in convention group were given physical therapy against VTE , while in anticoagulation group were given add-on low-molecular-weight heparin sodium against VTE once the stopping of blood bleeding was achieved. Safety parameters were recorded including VTE incidence, blood loss indexes, hemorrhage-related complications, incidence of heparin-induced thrombopenia (HIT) and blood coagulation function indicators.ResultsThirteen patients presented with VTE, with 10 patients (17%) in convention group versus 3 patients (5%) in anticoagulation group (P 0.05). HIT was not noted in anticoagulation group. At the endpoint of evaluation, no significant differences were noted between the two groups with regard to changes in prothrombin time (PT), activated partial thromboplastin time (APTT) and D-dimers (P>0.05); however, convention group versus anticoagulation group showed significant differences in international normalized ratio (INR) (0.97±0.10 vs.1.03±0.17) , fibrin (Fib)[(4.85±1.37)g/L vs.(4.01±1.16)g/L] and platelet (PLT) [(317.68±141.71)×109 / L vs. (422.20±178.16)×109/L] (P<0.05).ConclusionIn the early stage of trauma, low-molecular-weight heparin anticoagulation therapy can significantly reduce the incidence of VTE without increasing the risk of bleeding.Key words: Venous thromboembolism; Wounds and injuries; Anticoagulants; Heparin, low-molecular-weight" @default.
- W3029307944 created "2020-06-05" @default.
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- W3029307944 date "2016-08-15" @default.
- W3029307944 modified "2023-09-26" @default.
- W3029307944 title "Efficacy and safety of early low-molecular-weight heparin sodium in prevention of posttraumatic venous thromboembolism" @default.
- W3029307944 doi "https://doi.org/10.3760/cma.j.issn.1001-8050.2016.08.014" @default.
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