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- W3029323281 abstract "目的探讨BCR-ABL阳性微分化型急性髓系白血病（AML）的诊疗及预后。方法回顾性分析南方医科大学南方医院通过细胞形态学、免疫学、细胞遗传学及分子生物学方法确诊的1例BCR-ABL阳性AML微分化型（M0）患者，并予IA3+7方案联合达沙替尼进行诱导化疗。结果患者形态学可见分类不明细胞占0.745，形态学及细胞化学无髓系分化证据，过氧化物酶染色阳性细胞占0.2。免疫分型主要表达CD34、CD38、CD36、CD13dim、CD33、CD71dim、CD19dim、CD10、HLA-DR分化抗原，基本无cCD22、cMPO表达。荧光原位杂交示BCR-ABL1融合基因82%阳性，IGH缺失阳性；染色体示46，XX，t（9；22）（q34；q11.2）[8]/46，XX[22]；聚合酶链反应结果示BCR-ABL1 p190阳性。经IA联合达沙替尼化疗后达到完全缓解，但因合并中枢神经系统白血病，治疗无效死亡。结论BCR-ABL阳性微分化型AML发病率低，尚无统一治疗方案，以传统AML化疗方案为主，联合酪氨酸激酶抑制剂可能受益，但预后差。" @default.
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- W3029323281 date "2019-11-25" @default.
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- W3029323281 title "BCR-ABL positive minimally differentiated acute myeloid leukemia: report of one case and review of literature" @default.
- W3029323281 doi "https://doi.org/10.3760/cma.j.issn.1009-9921.2019.11.011" @default.
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