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- W3029336435 abstract "目的 探讨醋酸铅(PbAc)对大鼠脑细胞凋亡的诱发作用及对bcl-2基因表达的影响. 方法 SD大鼠腹腔分别注射PbAc 25、50、100 mg/kg 5 d,第6天用流式细胞仪分别测定其大脑皮层、海马和小脑组织的细胞凋亡率和bcl-2基因的表达产物Bcl-2蛋白含量. 结果 染铅大鼠大脑皮层、海马、小脑细胞凋亡率(%):25 mg/kg PbAc组为5.80±0.87、4.82±0. 37、4.82±1.23,50 mg/kg组值高于25 mg/kg组,100 mg/kg组值高于50 mg/kg组,均比对照组(1.40±0.70、2.00±0.63、1.66±0.49)高,差异有显著性(P＜0.01);并有剂量-反应关系(r值分别为0.998、0.989、0.997).染铅大鼠大脑皮层、海马、小脑bcl-2基因表达(FI指数):25 mg/kg PbAc组为0.68±0.03、0.61±0.06、0.69±0.05;50 mg /kg、100 mg/kg组值均与25 mg/kg组接近,但均比对照组(1.00±0.13、1.00±0.17、1. 00±0.13)降低,差异有显著性(P＜0.01);并有剂量-反应关系(r值分别为0.886、0 .787、0.832).大鼠大脑皮层、海马和小脑细胞凋亡率与Bcl-2含量呈负相关(r值分别为-0.750、-0.509、-0.667). 结论铅可以诱发大鼠脑细胞凋亡,其机制可能与脑组织内bcl-2基因表达下调有关." @default.
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- W3029336435 date "2000-07-20" @default.
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- W3029336435 title "Effect of lead acetate on the apoptosis and the expression of bcl-2 in rat brain" @default.
- W3029336435 doi "https://doi.org/10.3760/cma.j.issn.1001-9391.2000.04.012" @default.
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