Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029340444> ?p ?o ?g. }
- W3029340444 abstract "Abstract Aging causes morphological and functional changes in the cerebellum. This work aimed to demonstrate the implication of JAK1/STAT3/SOCS3 on aging–induced changes of rat cerebellum. Thirty male rats were divided into: adult (12 months), early senile (24 months) and late senile (32 months) groups. Immunohistochemical reaction of the cerebellum to GFAP and caspase-3 was assessed and the expression of JAK1, STAT3, SOCS3 proteins was also evaluated. TNFα as well as the activities of malondialdehyde (MDA) and reduced glutathione (GSH) in cerebellar tissue were also measured. The cerebellum of late senile rats revealed more degenerative changes than early senile rats in the form of increase in GFAP and caspase-3 immunoreaction. Additionally, there was decrease in JAK1and STAT3 expression in early and late senile rats and increase in SOCS3 when compare early and late senile groups with adult one. Enhancement of TNFα was noticed with aging as well as significant decrease in GSH and increase in MDA in early senile group. Moreover, late senile group revealed significant decrease in GSH and increase in MDA. It could be concluded that aging resulting in variable changes of the cerebellum as detected by morphological changes, immunohistochemical reactions of caspase-3 and GFAP and expression of JAK1/STAT3/SOCS3 proteins. Additionally, inflammatory marker TNFα and the activity of oxidative/antioxidative stress markers; malondialdehyde (MDA) and reduced glutathione (GSH) were also affected with aging." @default.
- W3029340444 created "2020-06-05" @default.
- W3029340444 creator A5016435576 @default.
- W3029340444 creator A5036688319 @default.
- W3029340444 date "2020-06-01" @default.
- W3029340444 modified "2023-10-01" @default.
- W3029340444 title "Implication of JAK1/STAT3/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study" @default.
- W3029340444 cites W1592706250 @default.
- W3029340444 cites W1821858011 @default.
- W3029340444 cites W1967500550 @default.
- W3029340444 cites W1967657570 @default.
- W3029340444 cites W1968143827 @default.
- W3029340444 cites W1973454407 @default.
- W3029340444 cites W1977884779 @default.
- W3029340444 cites W1981694995 @default.
- W3029340444 cites W1996784724 @default.
- W3029340444 cites W2000913269 @default.
- W3029340444 cites W2002117801 @default.
- W3029340444 cites W2003646464 @default.
- W3029340444 cites W2007064404 @default.
- W3029340444 cites W2022127898 @default.
- W3029340444 cites W2023751659 @default.
- W3029340444 cites W2025098556 @default.
- W3029340444 cites W2028189293 @default.
- W3029340444 cites W2028868339 @default.
- W3029340444 cites W2035279182 @default.
- W3029340444 cites W2044227662 @default.
- W3029340444 cites W2044541191 @default.
- W3029340444 cites W2049691960 @default.
- W3029340444 cites W2059099306 @default.
- W3029340444 cites W2060883530 @default.
- W3029340444 cites W2062451160 @default.
- W3029340444 cites W2066858330 @default.
- W3029340444 cites W2067476313 @default.
- W3029340444 cites W2085813350 @default.
- W3029340444 cites W2087277393 @default.
- W3029340444 cites W2098439437 @default.
- W3029340444 cites W2103618586 @default.
- W3029340444 cites W2121860798 @default.
- W3029340444 cites W2125178477 @default.
- W3029340444 cites W2125443686 @default.
- W3029340444 cites W2137062754 @default.
- W3029340444 cites W2139898307 @default.
- W3029340444 cites W2148992333 @default.
- W3029340444 cites W2160779535 @default.
- W3029340444 cites W2163759450 @default.
- W3029340444 cites W2166192872 @default.
- W3029340444 cites W2168574111 @default.
- W3029340444 cites W2168986469 @default.
- W3029340444 cites W2172781613 @default.
- W3029340444 cites W2309453014 @default.
- W3029340444 cites W4247441327 @default.
- W3029340444 cites W4252471889 @default.
- W3029340444 doi "https://doi.org/10.1038/s41598-020-64050-z" @default.
- W3029340444 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7264275" @default.
- W3029340444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32483368" @default.
- W3029340444 hasPublicationYear "2020" @default.
- W3029340444 type Work @default.
- W3029340444 sameAs 3029340444 @default.
- W3029340444 citedByCount "5" @default.
- W3029340444 countsByYear W30293404442020 @default.
- W3029340444 countsByYear W30293404442021 @default.
- W3029340444 countsByYear W30293404442022 @default.
- W3029340444 countsByYear W30293404442023 @default.
- W3029340444 crossrefType "journal-article" @default.
- W3029340444 hasAuthorship W3029340444A5016435576 @default.
- W3029340444 hasAuthorship W3029340444A5036688319 @default.
- W3029340444 hasBestOaLocation W30293404441 @default.
- W3029340444 hasConcept C126322002 @default.
- W3029340444 hasConcept C134018914 @default.
- W3029340444 hasConcept C181199279 @default.
- W3029340444 hasConcept C204232928 @default.
- W3029340444 hasConcept C2776151105 @default.
- W3029340444 hasConcept C2778401633 @default.
- W3029340444 hasConcept C2779134260 @default.
- W3029340444 hasConcept C2779652256 @default.
- W3029340444 hasConcept C502032728 @default.
- W3029340444 hasConcept C538909803 @default.
- W3029340444 hasConcept C55493867 @default.
- W3029340444 hasConcept C68026918 @default.
- W3029340444 hasConcept C71924100 @default.
- W3029340444 hasConcept C86803240 @default.
- W3029340444 hasConceptScore W3029340444C126322002 @default.
- W3029340444 hasConceptScore W3029340444C134018914 @default.
- W3029340444 hasConceptScore W3029340444C181199279 @default.
- W3029340444 hasConceptScore W3029340444C204232928 @default.
- W3029340444 hasConceptScore W3029340444C2776151105 @default.
- W3029340444 hasConceptScore W3029340444C2778401633 @default.
- W3029340444 hasConceptScore W3029340444C2779134260 @default.
- W3029340444 hasConceptScore W3029340444C2779652256 @default.
- W3029340444 hasConceptScore W3029340444C502032728 @default.
- W3029340444 hasConceptScore W3029340444C538909803 @default.
- W3029340444 hasConceptScore W3029340444C55493867 @default.
- W3029340444 hasConceptScore W3029340444C68026918 @default.
- W3029340444 hasConceptScore W3029340444C71924100 @default.
- W3029340444 hasConceptScore W3029340444C86803240 @default.
- W3029340444 hasIssue "1" @default.
- W3029340444 hasLocation W30293404441 @default.
- W3029340444 hasLocation W30293404442 @default.
- W3029340444 hasLocation W30293404443 @default.