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- W3029353310 abstract "Bronchiectasis is a chronic respiratory disease characterised by abnormal and irreversible dilatation and distortion of the smaller airways.The vast majority of patients in China are non-cystic fibrosis bronchiectasis.Non-cystic fibrosis bronchiectasis is usually associated with recurrent infection, immunodeficiency or autoimmune diseases.The vicious cycle of bacterial colonization, airway inflammation, and airway structural damage results in bronchiectasis.Airway inflammation is the key of the cycle.There are a large variety of causative factors that have been identified for bronchiectasis; All of these compromises the function of the immune response to fight infection.Despite aggressive treatment, most patients will have persistent disease.Manipulating the immune response in bronchiectasis may potentially have therapeutic potential.This review focuses on the main immunoregulatory mechanism associated with the pathogenesis of bronchiectasis, and summarizes the efficacy of immunomodulators on bronchiectasis in combination with the recent clinical trials.Key words: Bronchiectasis; Immunoregulation; Mechanism; Therapy" @default.
- W3029353310 created "2020-06-05" @default.
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- W3029353310 date "2019-03-20" @default.
- W3029353310 modified "2023-09-23" @default.
- W3029353310 title "The immunoregulatory mechanism of bronchiectasis and the progress of immunomodulatory therapy" @default.
- W3029353310 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2019.06.012" @default.
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