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- W3029354830 abstract "Objective To explore the intervention effect of mouse nerve growth factor on reducing the release of serum NSE and neurological protection in the children with neonatal hypoxic-ischemic encephalopathy (HIE).Method 89 patients with moderate to severe HIE was chosen,and then were randomly divided into a control group (n=44) and an observation group (n=45) with stratified method.Both groups were treated with conventional therapy; in addition,the control group administered brain protein citicoline,and the observation group took mNGF.The time of symptoms improvement,behavioral neurological score (NBNA),serum NSE and so on were compared between the 2 groups.After 1 years' follow-up,smart developmental quotient (DQ) of the two groups were compared.Results The improvement times of awareness,muscle tone,reflex recovery,and seizures were significantly shorter in the observation group than in the control group (P ＜ 0.05).Day 1-3 of the treatment,there was no statistical difference in NBNA score (28.44 ± 2.36 vs.28.42 ± 2.32) between the observation group and the control group(P ＞ 0.05); but day 4-6 and 7-10,there were statistical differences (32.78 ± 2.33 vs.30.01 ± 2.35,37.23 ± 2.01 vs.33.13 ± 2.09,P ＜ 0.05).Before the treatment,there were no statistical differences in serum S-100B and NSE between the 2 groups (P ＞ 0.05);3 and 7 days after the treatment,the serum S-100B and NSE were (17.31 ± 2.11) and (12.39 ± 1.77) were in the observation group and were (20.83 ± 2.31),(14.93 ± 1.83) in the control group,respectively,with statistical differences(P ＜ 0.05).After the 1-year follow-up,DQ normal rate was statistically higher in the observation group than in the control group (86.7％ vs.61.4％,P ＜ 0.05).Conclusion mNGF for neonatal hypoxic-ischemic encephalopathy can significantly reduce serum NSE release,protect nerve function,and improve the intellectual development of children's normal rate.Key words: Behavioral neurological assessment; Mouse nerve growth factor; Intelligent Quotient; Hypoxic-ischemic encephalopathy" @default.
- W3029354830 created "2020-06-05" @default.
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- W3029354830 date "2013-11-01" @default.
- W3029354830 modified "2023-09-24" @default.
- W3029354830 title "Mouse nerve growth factor for neonatal hypoxic-ischemic encephalopathy" @default.
- W3029354830 doi "https://doi.org/10.3760/cma.j.issn.1007-1245.2013.21.017" @default.
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