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- W3029355841 abstract "Objective To investigate the correlation of polymorphism of intron 8 (IVS-8) 6C11A /6T11G of metastasis suppressor gene KAI1/CD82 with the occurrence and metastasis of colorectal cancer.Methods From 135 healthy individuals and 115 patients with colorectal cancer, genomic DNA was extracted from peripheral blood, and their clinical data and pathological findings were retrieved.Correlation of the polymorphism at gene splicing region of the KAI1 IVS-8 with the occurrence and metastasis of colorectal cancer was analyzed in a case-control study by denaturing high-performance liquid chromatography (DHPLC) analysis.Results Mutant allelotype 6T11G of KAI1/CD82 gene IVS-8 was detected in 30.9% of healthy individuals (84/135) and 31.3% of colorectal cancer patients (72/155) , with no significant difference between the two groups (P=0.963).The genotypes did not differ between younger (＜50 years) and older patients (=50 years) (P>0.05), between male and female(P>0.05), or among common pathological types including tubular or tubulopapillary adenocarcinoma and mucinous adenocarcinoma (P=0.633).The prevalence of genotypes differed among pathological stages, but without statistical significance (P=0.267).However, a statistical difference was shown between patients with and without lymph node invasion [6C11A detected in 62.5% vs 76.5% of patients with (80/128) and without metastases (78/102); 6T11G detected in 37.5% vs 23.5% of patients with (48/128) and without metastases (24/102) ; (P=0.032) ].Conclusion The genetic polymorphism of IVS-8 in KAI1/CD82 gene may not be related with occurrence, pathological types of colorectal cancer but may play a role in lymph node metastasis, implicating that screening of 6C11A /6T11G polymorphism can be used to identify the prognosis of colorectal cancer patients.Key words: Polymorphism; Colorectal cancer; Metastasis; Denaturing high-performance liquid chromatoeraphy; KAI1/CD82" @default.
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- W3029355841 date "2011-02-15" @default.
- W3029355841 modified "2023-09-27" @default.
- W3029355841 title "Polymorphism of metastasis suppressor gene KAI1/CD82 detected using denaturing high-performance liquid chromatography techniques and its correlation with occurrence and metastasis of colorectal cancer" @default.
- W3029355841 doi "https://doi.org/10.3760/cma.j.issn.1674-1927.2011.01.011" @default.
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