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- W3029367074 abstract "ObjectiveTo investigate the clinical characteristics and the risk factors for chronic complications in hospitalized early-onset type 2 diabetic mellitus patients.MethodsThe clinical data of 462 hospitalized type 2 diabetic mellitus patients were retrospectively analyzed. The patients were divided into early-onset group (age of diagnosis ≤40 years, 120 cases) and late-onset group (age of diagnosis > 40 years, 342 cases) according to the age of diagnosis of diabetes. The clinical characteristics were compared and risk factors for chronic complications of early-onset type 2 diabetes were explored.ResultsThe percentage of family history of diabetes, fasting plasma glucose, triglyceride and diastolic blood pressure in early-onset group were significantly higher than those in late-onset group: 70.0% (84/120) vs. 52.3% (179/342), (8.68 ± 3.08) mmol/L vs. (8.07 ± 2.74) mmol/L, 1.69 (1.06, 2.92) mmol/L vs. 1.48 (1.07, 2.24) mmol/L and (84 ± 10) mmHg (1 mmHg = 0.133 kPa) vs. (81 ± 10) mmHg, and there were statistical differences (P 0.05). The incidences of peripheral vasculopathy and cerebrovascular disease in early-onset group were significantly lower than those in late-onset group: 13.3% (16/120) vs. 24.3% (83/342) and 11.7% (14/120) vs. 22.8% (78/342), but the incidence of diabetic nephropathy was significantly higher than that in late-onset group: 37.5% (45/120) vs. 27.8% (95/342), and there were statistical differences (P 0.05). Multivariate Logistic stepwise regression analysis result showed that age, duration of diabetes, hypertension, smoking, levels of glycated hemoglobin and triglyceride were the risk factors for chronic complications in early-onset type 2 diabetic mellitus patients.ConclusionsThe clinical characteristics are different between early-onset and late-onset type 2 diabetic mellitus patients. Early-onset patients are more prone to diabetic nephropathy, while late-onset patients are prone to macrovascular diseases such as peripheral vascular disease and cerebrovascular disease. Comprehensive management should be administered for early-onset type 2 diabetic mellitus patients to prevent chronic complications especially microvascular complications.Key words: Diabetes mellitus, type 2; Diabetes complications; Risk factors; Disease attributes" @default.
- W3029367074 created "2020-06-05" @default.
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- W3029367074 date "2017-09-05" @default.
- W3029367074 modified "2023-09-24" @default.
- W3029367074 title "Investigation on the clinical characteristics and risk factors for chronic complications in hospitalized early-onset type 2 diabetic mellitus patients" @default.
- W3029367074 doi "https://doi.org/10.3760/cma.j.issn.1673-4904.2017.09.001" @default.
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