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- W3029382482 abstract "Objective To investigate the potential pathogenicity of Mycoplasma penetrans(M. penetrans) and the molecular mechanisms that is responsible for the induction of inducible nitric oxide synthase(iNOS) gene expression in mouse macrophages stimulated by lipid-associated membrane proteins(LAMPs) prepared from M. penetrans. Methods Mouse macrophages were stimulated by M. penetrans LAMPs to analyze the production of nitric oxide(NO), the expression of iNOS was detected by RT-PCR and Western blot. The activity of nuclear factor κB(NF-κB) and the effects of pyrrolidine dithiocarbamate(PDTC), an inhibitor of NF-κB, on the production of nitric oxide and the expression of iNOS was also examined in mouse macrophages treated with M. penetrans LAMPs by indirect immunofluorescence and Western blot. Results M. penetrans LAMPs stimulated mouse macrophages to produce nitric oxide in a dose- and time-dependent manner. mRNA and protein of iNOS were also induced in response to LAMPs and inhibited by PDTC. M. penetrans LAMPs could trigger NF-κB activation, a possible mechanism for the induced iNOS expression. Conclusion M. penetrans may be an important etiological factor due to the ability of LAMPs to stimulate the expression of iNOS, which is probably mediated by the activation of NF-κB." @default.
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- W3029382482 date "2004-01-01" @default.
- W3029382482 modified "2023-09-22" @default.
- W3029382482 title "Expression of inducible nitric oxide synthase in murine macrophages stimulated with Mycoplasma penetrans lipid-associated membrane proteins by activating nuclear factor κB" @default.
- W3029382482 hasPublicationYear "2004" @default.
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