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- W3029385220 abstract "Toll-like receptors (TLRs) belong to the family of pattern recognition receptors.TLRs recognize pathogen-associated molecular patterns(PAMP) of the invading microorganisms and trigger immune reaction via a series of signal transductions.TLRs also play an important role in regulating both innate and adaptive immunities.So far there have been 10 different TLRs found in human.Recent researches show that the expression of TLR7 in immune cells is closely linked to allergic and autoimmune diseases, such as allergic asthma and systemic lupus erythematosus(SLE). Activation of TLR7 plays a significant role in the initiation and development of asthma and SLE, suggesting that TLR7 can be a potential target in treating these diseases.Key words: TLR7; Allergic Asthma; Systemic Lupus Erythematosus; Immunotherapy" @default.
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- W3029385220 date "2017-03-05" @default.
- W3029385220 modified "2023-09-24" @default.
- W3029385220 title "Toll like receptor 7-targeted therapy: examples for allergic asthma and autoimmune disease" @default.
- W3029385220 doi "https://doi.org/10.3760/cma.j.issn.1673-4394.2017.02.020" @default.
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