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• W3029388433 abstract "ObjectiveTo investigate the genetic polymorphism of 13 cytokines genes in Han individual children from Beijing area.MethodsThe polymerase chain reaction-sequence specific primers(PCR-SSP) method was used to determine cytokine gene polymorphism including interleukin(IL)-1α(-889C/T), IL-1β(-511C/T, + 3942T/C), IL-1R(pst1 1970C/T), IL-1RA(mspa1 11100T/C), IL-4Ra(+ 1902G/A), IL-12(-1188C/A), interferon(IFN)-γ(+ 874A/T), transforming growth factor(TGF)-β1(codon10C/T, codon25G/C), tumor necrosis factor)(TNF)-α(-308G/A, -238G/A), IL-2(-330T/G, + 166G/T), IL-4(-1098 T/G, -590 T/C, -33 T/C), IL-6(-174G/C, nt565G/A), IL-10(-1082G/A, -819C/T, -592A/C) 13 cytokines genes in 210 unrelated healthy Han individuals from Beijing area.Results(1) Cytokine genes with frequencies more than or equal to 95 percent included IL-1β+ 3962 C, TGF-β Codon 25 G, IL-6 -174 G, IL-6 nt565 G, TNF-α-308 G and TNF-α-238 G alleles; while cytokine genes with frequencies less than or equal to 5 persent included IL-1β+ 3962 T, TGF-β Codon 25 C, IL-6-174C, IL-6 nt 565 A, TNF-α-308 A and TNF-α-238 A alleles.(2) The frequency of the high-producer-type GCC haplotype in IL-10 gene was 8.27%, while the low-producer-type ATA was 59.11%.The frequency of the high-producer-type TG haplotype in the TGF-β gene was 49.77%, while the low-producer-type CC was 0.The frequencies of the high-producer-types AG and AA haplotypes in the TNF-α gene were 3.34%, while those of the low-producer-types GG and GA were 96.67%.The frequency of the high-producer-types T/G genotype in the IL-2-330 gene was 11.90%, while those of the low-producer-types T/T and T/G were 88.10%.The frequencies of the high-producer-types G/G and G/C genotypes in the IL-6-174 gene were 99.52%, while that of the low-producer-types C/C was 0.48%.The frequency of the high-producer-types T/T genotype in the INF-γ+ 874 gene was 1.90%, and the frequency of the medium-producer-types T/A in the INF-γ+ 874 gene was 22.86%, while of the low-producer-types A/A was 75.24%.(3) New genotypes were found: the frequency of IL-2(-330, + 166) GG/GT/TT genotype was 1.90%, and the frequency of IL-2(-330, + 166) TG/GG/GT/TT genotype was 0.48%, The frequency of IL-6(-174, nt565) CG/CG genotype was 0.48%, the frequency of IL-6(-174, nt565)GA/GG genotype was 1.90%, The frequency of IL-6(-174, nt565) GG/GA/CA genotype was 0.48%, The frequency of IL-10(-1082, -819, -592) GCC/ATC/ATA genotype was 0.95%, The frequency of IL-10(-1082, -819, -592) ACC/ACA/ATC/ATA genotype was 35.71%, The frequency of IL-10(-1082, -819, -592) GCC/ACC/ACA/ATC/ATA genotype was 0.48%.ConclusionThe genetic polymorphism of cytokine genes in Han individuals from Beijing area is different from other areas of China with higher frequencies of IL-10(-1082, -819, -592) ACC/ACA/ATC/ATA genotype.Key words: Cytokine; Gene polymorphism; Genotype; Haplotype" @default.
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• W3029388433 date "2013-08-05" @default.
• W3029388433 modified "2023-09-23" @default.
• W3029388433 title "Genetic polymorphism of cytokine genes in Han children in Beijing area" @default.
• W3029388433 doi "https://doi.org/10.3760/cma.j.issn.2095-428x.2013.15.013" @default.
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