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- W3029389622 abstract "目的分别测定慢性病毒性肝炎、肝炎肝硬变患者血清转化生长因子β1(TGF-β1)、肿瘤坏死因子(TNF-α),探讨两者在肝纤维化中的作用.方法采用酶联免疫吸附试验测定107例慢性肝病患者血清TGF-β1、TNF-α水平.23例肝穿观察光镜下肝组织病理分期.结果慢性病毒性肝炎轻、中、重度组及肝硬变组患者血清TGF-βl(μg/L)分别为14.2±5.9、20.1±7.0、30.2±6.7及32.6±7.5,血清TNF-α(pg/L)分别为6.1±3.2、29.8±18.6、57.3±22.5和96.7±38.2,两者均随肝炎程度加重呈升高趋势;肝活检结果显示这两个指标与肝纤维化的程度具有相关关系;它们均与HA的变化呈正相关.结论TcF-β1、TNF-α与肝纤维化的形成有关." @default.
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- W3029389622 date "2001-07-20" @default.
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- W3029389622 title "Relationship Between Transforming Growth Factor β1 and Tumor Necrosis Factor α with Liver Fibrosis in Chronic Viral Hepatitis Subjects" @default.
- W3029389622 doi "https://doi.org/10.3760/cma.j.issn.1008-1372.2001.07.007" @default.
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