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- W3029417503 abstract "ObjectiveWhen intravenous immunoglobulin (IVIG) given during the acute phase of Kawasaki disease (KD), rapidly reverses clinical symptoms and prevents cardiac disease. The mechanism of IVIG′s therapeutic and prophylactic activity in KD is unknown but is assumed to involve immune mechanisms. The present study aimed at investigating effects of IVIG on TH1/TH2 functional state and mechanism of immunologic therapy of the acute phase from children with KD.MethodsThe levels of IL-4 and INF-γ in the supernatants of cultured peripheral blood mononuclear cells (PBMC) for 72 hours , or plasma IgE were measured by using ELISA and CD4+ CD30+ T cells of cultured PBMC for 72 hours were analyzed by using FACS in the pre- or post-treatment (3~5days) with IVIG during from the acute phase 15 children with KD (male 9, female 6, and age 2.3±1.5 years), respectively. Fifteen healthy children (male 8, female 7, and age 2.6±1.4 years) were served as normal controls.ResultsExpression rate of CD4+ CD30+ T cells was markedly higher in the pre-treatment specimens [(16.9±7.5)%] with IVIG during the acute phase of KD than in the post-treatment[(3.8±4.0)%](t=7.02, P 0.05) specimens. But it was markedly lower in the pre-treatment than in normal controls specimens [(1 099±661)ng/L] (u=1.97, P 0.05).ConclusionTH1/TH2 functional state in the acute phase of KD was unbalanced. The effects of TH2 were increased. TH1/TH2 imbalance during the acute phase of KD was improved and the enhanced TH2 function were rapidly reversed by IVIG.Key words: Mucocutaneous lymph node syndrome; Immunoglobulins, intrarenous; TH1 cells/TH2 cells; Antigens, CD30" @default.
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- W3029417503 date "2002-02-16" @default.
- W3029417503 modified "2023-09-27" @default.
- W3029417503 title "Effects of IVIG on TH1/TH2 of children with Kawasaki disease" @default.
- W3029417503 doi "https://doi.org/10.3760/cma.j.issn.0578-1310.2002.02.105" @default.
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